Cholinergic Modulation of Neuroinflammation : Focus on α7 Nicotinic Receptor

All nervous system pathologies (e.g., neurodegenerative/demyelinating diseases and brain tumours) develop neuroinflammation, a beneficial process during pathological events, aimed at removing damaged cells, toxic agents, and/or pathogens. Unfortunately, excessive inflammation frequently occurs during nervous system disorders, becoming a detrimental event capable of enhancing neurons and myelinating glial cell impairment, rather than improving their survival and activity. Consequently, targeting the neuroinflammation could be relevant for reducing brain injury and rescuing neuronal and glial cell functions. Several studies have highlighted the role of acetylcholine and its receptors in the regulation of central and peripheral inflammation. In particular, α7 nicotinic receptor has been described as one of the main regulators of the "brain cholinergic anti-inflammatory pathway". Its expression in astrocytes and microglial cells and the ability to modulate anti-inflammatory cytokines make this receptor a new interesting therapeutic target for neuroinflammation regulation. In this review, we summarize the distribution and physiological functions of the α7 nicotinic receptor in glial cells (astrocytes and microglia) and its role in the modulation of neuroinflammation. Moreover, we explore how its altered expression and function contribute to the development of different neurological pathologies and exacerbate neuroinflammatory processes.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

International journal of molecular sciences - 22(2021), 9 vom: 06. Mai

Sprache:

Englisch

Beteiligte Personen:

Piovesana, Roberta [VerfasserIn]
Salazar Intriago, Michael Sebastian [VerfasserIn]
Dini, Luciana [VerfasserIn]
Tata, Ada Maria [VerfasserIn]

Links:

Volltext

Themen:

α7 nicotinic receptors
Acetylcholine
Alpha7 Nicotinic Acetylcholine Receptor
Cholinergic Agents
Glial cells
Journal Article
Metabotropic signalling
Neuroinflammation
Review

Anmerkungen:

Date Completed 22.06.2021

Date Revised 22.06.2021

published: Electronic

Citation Status MEDLINE

doi:

10.3390/ijms22094912

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM326148485