Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease Progression
© 2021 International Parkinson and Movement Disorder Society..
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative movement disorder. Observational studies suggest higher levels of plasma urate may protect against Parkinson's risk and progression; however, causality cannot be established.
OBJECTIVES: This study set out to determine whether there is a true causal association between urate levels and PD age at onset (AAO) and progression severity using recently released PD AAO and progression genome-wide association study (GWAS) data.
METHODS: A large two-sample Mendelian randomization design was employed, using genetic variants underlying urate levels and the latest GWAS data for PD outcomes.
RESULTS: This study found no causal association between urate levels and Parkinson's risk, AAO, or progression severity.
CONCLUSIONS: Our results predict increasing urate levels as a therapeutic strategy is unlikely to benefit PD patients. © 2021 International Parkinson and Movement Disorder Society.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Movement disorders : official journal of the Movement Disorder Society - 36(2021), 9 vom: 15. Sept., Seite 2182-2187 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Coneys, Rachel [VerfasserIn] |
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| Links: |
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| Themen: |
268B43MJ25 |
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| Anmerkungen: |
Date Completed 13.10.2021 Date Revised 13.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mds.28662 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM32605376X |
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| 245 | 1 | 0 | |a Mendelian Randomisation Finds No Causal Association between Urate and Parkinson's Disease Progression |
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| 500 | |a Date Completed 13.10.2021 | ||
| 500 | |a Date Revised 13.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 International Parkinson and Movement Disorder Society. | ||
| 520 | |a BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative movement disorder. Observational studies suggest higher levels of plasma urate may protect against Parkinson's risk and progression; however, causality cannot be established | ||
| 520 | |a OBJECTIVES: This study set out to determine whether there is a true causal association between urate levels and PD age at onset (AAO) and progression severity using recently released PD AAO and progression genome-wide association study (GWAS) data | ||
| 520 | |a METHODS: A large two-sample Mendelian randomization design was employed, using genetic variants underlying urate levels and the latest GWAS data for PD outcomes | ||
| 520 | |a RESULTS: This study found no causal association between urate levels and Parkinson's risk, AAO, or progression severity | ||
| 520 | |a CONCLUSIONS: Our results predict increasing urate levels as a therapeutic strategy is unlikely to benefit PD patients. © 2021 International Parkinson and Movement Disorder Society | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Mendelian randomization | |
| 650 | 4 | |a Parkinson's disease | |
| 650 | 4 | |a genome-wide association-study | |
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| 700 | 1 | |a Wood, Nicholas W |e verfasserin |4 aut | |
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