Trends and correlation between antibacterial consumption and carbapenem resistance in gram-negative bacteria in a tertiary hospital in China from 2012 to 2019

BACKGROUND: To investigate the trends and correlation between antibacterial consumption and carbapenem resistance in Gram-negative bacteria from 2012 to 2019 in a tertiary-care teaching hospital in southern China.

METHODS: This retrospective study included data from hospital-wide inpatients collected between January 2012 and December 2019. Data on antibacterial consumption were expressed as defined daily doses (DDDs)/1000 patient-days. Antibacterials were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. The trends in antimicrobial usage and resistance were analyzed by linear regression, while Pearson correlation analysis was used for assessing correlations.

RESULTS: An increasing trend in the annual consumption of tetracyclines, β-lactam/β-lactamase inhibitor (BL/BLI) combinations, and carbapenems was observed (P < 0.05). Carbapenem resistance in Acinetobacter baumannii (A. baumannii) significantly increased (P < 0.05) from 18% in 2012 to 60% in 2019. Moreover, significant positive correlations were found between resistance to carbapenems in A. baumannii (P < 0.05) and Escherichia coli (E. coli; P < 0.05) and consumption of carbapenems, while the resistance rate of A. baumannii to carbapenems was positively correlated with cephalosporin/β-lactamase inhibitor (C/BLI) combinations (P < 0.01) and tetracyclines usage (P < 0.05). We also found that use of quinolones was positively correlated with the resistance rate of Burkholderia cepacia (B. cepacia) to carbapenems (P < 0.05), and increasing uses of carbapenems (P < 0.01) and penicillin/β-Lactamase inhibitor (P/BLI) combinations (P < 0.01) were significantly correlated with reduced resistance of Enterobacter cloacae (E. cloacae) to carbapenems.

CONCLUSION: These results revealed significant correlations between consumption of antibiotics and carbapenem resistance rates in Gram-negative bacteria. Implementing proper management strategies and reducing the unreasonable use of antibacterial drugs may be an effective measure to reduce the spread of carbapenem-resistant Gram-negative bacteria (CRGN), which should be confirmed by further studies.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:21

Enthalten in:

BMC infectious diseases - 21(2021), 1 vom: 17. Mai, Seite 444

Sprache:

Englisch

Beteiligte Personen:

Liang, Chunhong [VerfasserIn]
Zhang, Xueyan [VerfasserIn]
Zhou, Lijuan [VerfasserIn]
Meng, Guangyi [VerfasserIn]
Zhong, Liqiu [VerfasserIn]
Peng, Pingzhi [VerfasserIn]

Links:

Volltext

Themen:

Anti-Bacterial Agents
Antibacterial consumption
Beta-Lactamase Inhibitors
Carbapenems
Cephalosporins
Drug resistance
Gram-negative bacteria
Journal Article
Microbial
Tetracyclines

Anmerkungen:

Date Completed 01.06.2021

Date Revised 01.06.2021

published: Electronic

Citation Status MEDLINE

doi:

10.1186/s12879-021-06140-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM325522340