Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade : Implications for Cancer Therapy

Copyright © 2021 Liu, Luo, Huang, Chen and Zhou..

Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to distant organs is a multistep process known as the metastatic cascade, including local invasion, intravasation, survival in the circulation, extravasation, and colonization. Each of these steps is driven by the acquisition of genetic and/or epigenetic alterations within cancer cells, leading to subsequent transformation of metastatic cells. Epithelial-mesenchymal transition (EMT), a cellular process mediating the conversion of cell from epithelial to mesenchymal phenotype, and its reverse transformation, termed mesenchymal-epithelial transition (MET), together endow metastatic cells with traits needed to generate overt metastases in different scenarios. The dynamic shift between these two phenotypes and their transitional state, termed partial EMT, emphasizes the plasticity of EMT. Recent advances attributed this plasticity to epigenetic regulation, which has implications for the therapeutic targeting of cancer metastasis. In this review, we will discuss the association between epigenetic events and the multifaceted nature of EMT, which may provide insights into the steps of the cancer metastatic cascade.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

Frontiers in oncology - 11(2021) vom: 10., Seite 657546

Sprache:

Englisch

Beteiligte Personen:

Liu, Qiu-Luo [VerfasserIn]
Luo, Maochao [VerfasserIn]
Huang, Canhua [VerfasserIn]
Chen, Hai-Ning [VerfasserIn]
Zhou, Zong-Guang [VerfasserIn]

Links:

Volltext

Themen:

Cancer therapy
Epigenetics
Epithelial–mesenchymal plasticity
Epithelial to mesenchymal transition
Journal Article
Metastatic cascade
Review

Anmerkungen:

Date Revised 18.05.2021

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fonc.2021.657546

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM325478619