Tumor Growth Rate as a New Predictor of Progression-Free Survival After Chordoma Surgery
© Congress of Neurological Surgeons 2021..
BACKGROUND: Currently, different postoperative predictors of chordoma recurrence have been identified. Tumor growth rate (TGR) is an image-based calculation that provides quantitative information of tumor's volume changing over time and has been shown to predict progression-free survival (PFS) in other tumor types.
OBJECTIVE: To explore the usefulness of TGR as a new preoperative radiological marker for chordoma recurrence.
METHODS: A retrospective single-institution study was carried out including patients reflecting these criteria: confirmed diagnosis of chordoma on pathological analysis, no history of previous radiation, and at least 2 preoperative thin-slice magnetic resonance images available to measure TGR. TGR was calculated for all patients, showing the percentage change in tumor size over 1 mo.
RESULTS: A total of 32 patients were retained for analysis. Patients with a TGR ≥ 10.12%/m had a statistically significantly lower mean PFS (P < .0001). TGR ≥ 10.12%/m (odds ratio = 26, P = .001) was observed more frequently in recurrent chordoma. In a subgroup analysis, we found that the association of Ki-67 labeling index ≥ 6% and TGR ≥ 10.12%/m was correlated with recurrence (P = .0008).
CONCLUSION: TGR may be considered as a preoperative radiological indicator of tumor proliferation and seems to preoperatively identify more aggressive tumors with a higher tendency to recur. Our findings suggest that the therapeutic strategy and clinical-radiological follow-up of patients with chordoma can be adapted also according to this new parameter.
| Errataetall: |
CommentIn: Neurosurgery. 2022 Jan 1;90(1):e19. - PMID 34982891 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
Neurosurgery - 89(2021), 2 vom: 15. Juli, Seite 291-299 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Passeri, Thibault [VerfasserIn] |
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| Links: |
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| Themen: |
Chordoma |
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| Anmerkungen: |
Date Completed 25.11.2021 Date Revised 22.03.2022 published: Print CommentIn: Neurosurgery. 2022 Jan 1;90(1):e19. - PMID 34982891 Citation Status MEDLINE |
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| doi: |
10.1093/neuros/nyab164 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Congress of Neurological Surgeons 2021. | ||
| 520 | |a BACKGROUND: Currently, different postoperative predictors of chordoma recurrence have been identified. Tumor growth rate (TGR) is an image-based calculation that provides quantitative information of tumor's volume changing over time and has been shown to predict progression-free survival (PFS) in other tumor types | ||
| 520 | |a OBJECTIVE: To explore the usefulness of TGR as a new preoperative radiological marker for chordoma recurrence | ||
| 520 | |a METHODS: A retrospective single-institution study was carried out including patients reflecting these criteria: confirmed diagnosis of chordoma on pathological analysis, no history of previous radiation, and at least 2 preoperative thin-slice magnetic resonance images available to measure TGR. TGR was calculated for all patients, showing the percentage change in tumor size over 1 mo | ||
| 520 | |a RESULTS: A total of 32 patients were retained for analysis. Patients with a TGR ≥ 10.12%/m had a statistically significantly lower mean PFS (P < .0001). TGR ≥ 10.12%/m (odds ratio = 26, P = .001) was observed more frequently in recurrent chordoma. In a subgroup analysis, we found that the association of Ki-67 labeling index ≥ 6% and TGR ≥ 10.12%/m was correlated with recurrence (P = .0008) | ||
| 520 | |a CONCLUSION: TGR may be considered as a preoperative radiological indicator of tumor proliferation and seems to preoperatively identify more aggressive tumors with a higher tendency to recur. Our findings suggest that the therapeutic strategy and clinical-radiological follow-up of patients with chordoma can be adapted also according to this new parameter | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chordoma | |
| 650 | 4 | |a Progression | |
| 650 | 4 | |a Skull base | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Tumor growth rate | |
| 700 | 1 | |a di Russo, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Champagne, Pierre-Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Bernat, Anne-Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Cartailler, Jérome |e verfasserin |4 aut | |
| 700 | 1 | |a Guichard, Jean Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Mammar, Hamid |e verfasserin |4 aut | |
| 700 | 1 | |a Giammattei, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Adle-Biassette, Homa |e verfasserin |4 aut | |
| 700 | 1 | |a George, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Mandonnet, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Froelich, Sébastien |e verfasserin |4 aut | |
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