Mechanochemical induction of wrinkling morphogenesis on elastic shells

Morphogenetic dynamics of tissue sheets require coordinated cell shape changes regulated by global patterning of mechanical forces. Inspired by such biological phenomena, we propose a minimal mechanochemical model based on the notion that cell shape changes are induced by diffusible biomolecules that influence tissue contractility in a concentration-dependent manner - and whose concentration is in turn affected by the macroscopic tissue shape. We perform computational simulations of thin shell elastic dynamics to reveal propagating chemical and three-dimensional deformation patterns arising due to a sequence of buckling instabilities. Depending on the concentration threshold that actuates cell shape change, we find qualitatively different patterns. The mechanochemically coupled patterning dynamics are distinct from those driven by purely mechanical or purely chemical factors, and emerge even without diffusion. Using numerical simulations and theoretical arguments, we analyze the elastic instabilities that result from our model and provide simple scaling laws to identify wrinkling morphologies.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:17

Enthalten in:

Soft matter - 17(2021), 18 vom: 12. Mai, Seite 4738-4750

Sprache:

Englisch

Beteiligte Personen:

Zakharov, Andrei [VerfasserIn]
Dasbiswas, Kinjal [VerfasserIn]

Links:

Volltext

Themen:

Journal Article

Anmerkungen:

Date Completed 17.05.2021

Date Revised 17.05.2021

published: Print

Citation Status PubMed-not-MEDLINE

doi:

10.1039/d1sm00003a

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM325301441