Multicolor fluorescence biosensors reveal a burning need for diversity in the single-cell metabolic landscape
Copyright © 2021 Elsevier Ltd. All rights reserved..
Although cellular heterogeneity has been described for metabolic pathways, the upstream mechanisms, the downstream consequences, and the flexibility and transmission of these preferences to daughter cells remains largely unknown. Using live-cell imaging, Kosaisawe et al. demonstrate that cellular metabolism, determined by glycolysis and ATP, is spontaneously heterogeneous, plastic, and regulatory.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Trends in endocrinology and metabolism: TEM - 32(2021), 8 vom: 07. Aug., Seite 537-539 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Islam, Md Torikul [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.02.2022 Date Revised 02.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.tem.2021.04.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Although cellular heterogeneity has been described for metabolic pathways, the upstream mechanisms, the downstream consequences, and the flexibility and transmission of these preferences to daughter cells remains largely unknown. Using live-cell imaging, Kosaisawe et al. demonstrate that cellular metabolism, determined by glycolysis and ATP, is spontaneously heterogeneous, plastic, and regulatory | ||
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