Histogram parameters derived from T1 and T2 weighted images correlate with tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
Copyright © 2021 Elsevier Inc. All rights reserved..
PURPOSE: The present study used histogram analysis values derived from T1- and T2- weighted (w) images to elucidate possible associations with Tumor-infiltrating lymphocytes (TIL) and Vimentin expression in head and neck squamous cell cancer (HNSCC).
MATERIALS AND METHODS: Overall, 28 patients (n = 8 female patient, 28.6%) with primary HNSCC of different localizations were involved in the study. Magnetic resonance imaging (MRI) was obtained on a 3 T MRI. The images were analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on biopsy samples before any form of treatment.
RESULTS: Several T1-derived parameters correlated with the expression of TIL within the stroma compartment: mean (r = 0.42, p = 0.025), p10 (r = 0.50, p = 0.007), p25 (r = 0.42, p = 0.025), median (r = 0.39, p = 0.036), and mode (r = 0.39, p = 0.04). No T2-derived parameter correlated with the TIL within the stroma compartment. Several T2-derived parameters correlated with the expression of TIL within the tumor compartment: mean (r = -0.52, p = 0.004), max (r = -0.43, p = 0.02), p10 (r = -0.38, p = 0.04), p25 (r = -0.53, p = 0.004), p75 (r = -0.52, p = 0.004), p90 (r = -0.48, p = 0.009), median (r = -0.52, p = 0.004), mode (r = -0.40, p = 0.03). Kurtosis derived from T2w images had significant higher values in tumor-rich tumors, compared to stroma-rich tumors, (mean 5.5 ± 0.5 versus 4.2 ± 1.2, p = 0.028).
CONCLUSIONS: Histogram analysis parameters derived from T1w and T2w images might be able to reflect tumor compartments and TIL expression in HNSCC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
Magnetic resonance imaging - 80(2021) vom: 31. Juli, Seite 127-131 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Meyer, Hans-Jonas [VerfasserIn] |
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| Links: |
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| Themen: |
Head and neck squamous cell cancer |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.mri.2021.05.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325228558 |
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| 100 | 1 | |a Meyer, Hans-Jonas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Histogram parameters derived from T1 and T2 weighted images correlate with tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 18.08.2021 | ||
| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: The present study used histogram analysis values derived from T1- and T2- weighted (w) images to elucidate possible associations with Tumor-infiltrating lymphocytes (TIL) and Vimentin expression in head and neck squamous cell cancer (HNSCC) | ||
| 520 | |a MATERIALS AND METHODS: Overall, 28 patients (n = 8 female patient, 28.6%) with primary HNSCC of different localizations were involved in the study. Magnetic resonance imaging (MRI) was obtained on a 3 T MRI. The images were analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on biopsy samples before any form of treatment | ||
| 520 | |a RESULTS: Several T1-derived parameters correlated with the expression of TIL within the stroma compartment: mean (r = 0.42, p = 0.025), p10 (r = 0.50, p = 0.007), p25 (r = 0.42, p = 0.025), median (r = 0.39, p = 0.036), and mode (r = 0.39, p = 0.04). No T2-derived parameter correlated with the TIL within the stroma compartment. Several T2-derived parameters correlated with the expression of TIL within the tumor compartment: mean (r = -0.52, p = 0.004), max (r = -0.43, p = 0.02), p10 (r = -0.38, p = 0.04), p25 (r = -0.53, p = 0.004), p75 (r = -0.52, p = 0.004), p90 (r = -0.48, p = 0.009), median (r = -0.52, p = 0.004), mode (r = -0.40, p = 0.03). Kurtosis derived from T2w images had significant higher values in tumor-rich tumors, compared to stroma-rich tumors, (mean 5.5 ± 0.5 versus 4.2 ± 1.2, p = 0.028) | ||
| 520 | |a CONCLUSIONS: Histogram analysis parameters derived from T1w and T2w images might be able to reflect tumor compartments and TIL expression in HNSCC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Head and neck squamous cell cancer | |
| 650 | 4 | |a Histogram analysis | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Tumor infiltrating lymphocyte | |
| 700 | 1 | |a Höhn, Anne Kathrin |e verfasserin |4 aut | |
| 700 | 1 | |a Surov, Alexey |e verfasserin |4 aut | |
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