Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma : a meta-analysis

© 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation..

PURPOSE: To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening.

METHODS: We updated the search (PubMed and Embase) for published literature as performed by our research group in 2014 and 2019. Trilateral retinoblastoma (TRb) patients were eligible for inclusion if identifiable as unique and the age at which TRb was diagnosed was available. The search yielded 97 new studies. Three new studies and eight new patients were included. Combined with 189 patients from the previous meta-analysis, the database included 197 patients. The main outcome was the percentage of asynchronous TRb in patients diagnosed before and after preset age thresholds of 6 and 12 months of age at retinoblastoma diagnosis.

RESULTS: Seventy-nine per cent of patients with pineoblastoma are diagnosed with retinoblastoma before the age of 12 months. However, baseline MRI screening at time of retinoblastoma diagnosis fails to detect the later diagnosed pineal TRb in 89% of patients. We modelled that an additional MRI performed at the age of 29 months picks up 53% of pineoblastomas in an asymptomatic phase. The detection rate increased to 72%, 87% and 92%, respectively, with 2, 3 and 4 additional MRIs.

CONCLUSIONS: An MRI of the brain in heritable retinoblastoma before the age of 12 months misses most pineoblastomas, while retinoblastomas are diagnosed most often before the age of 12 months. Optimally timed additional MRI scans of the brain can increase the asymptomatic detection rate of pineoblastoma.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:100

Enthalten in:

Acta ophthalmologica - 100(2022), 1 vom: 19. Feb., Seite e47-e52

Sprache:

Englisch

Beteiligte Personen:

de Jong, Marcus C [VerfasserIn]
Shaikh, Furqan [VerfasserIn]
Gallie, Brenda [VerfasserIn]
Kors, Wijnanda A [VerfasserIn]
Jansen, Robin W [VerfasserIn]
Dommering, Charlotte [VerfasserIn]
de Graaf, Pim [VerfasserIn]
Moll, Annette C [VerfasserIn]
Dimaras, Helen [VerfasserIn]
Shroff, Manohar [VerfasserIn]
Kivelä, Tero T [VerfasserIn]
Soliman, Sameh E [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
MRI
Magnetic resonance imaging
Meta-Analysis
PNET
Pineal gland
Pineoblastoma
Retinoblastoma
Review
Trilateral retinoblastoma

Anmerkungen:

Date Completed 28.01.2022

Date Revised 31.07.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/aos.14855

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324923651