Prevalence and serotyping of S. pneumoniae in a large vaccine-naive cohort of adults with cystic fibrosis

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..

We conducted a prospective, observational study at the Adult CF Center, Ospedale Policlinico, Milano, Italy, from March 2017 to September 2019 to assess the prevalence and serotypes of Streptococcus pneumoniae (SP) in adults with CF naive to pneumococcal vaccination. Spontaneous sputum samples from 129 patients were analyzed for SP DNA and serotyped. SP was found in 24 subjects (19%) and the most common serotypes were 19F (16%), 4 (6%), and 9VA (3%). Higher FEV1 and non-pseudomonas infection significantly associate with SP on sputum. These results define a subgroup of patients that might deserve implementation of microbiological techniques directed to pneumococcal detection.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 40(2021), 11 vom: 02. Nov., Seite 2443-2446

Sprache:

Englisch

Beteiligte Personen:

Gramegna, Andrea [VerfasserIn]
Aliberti, Stefano [VerfasserIn]
Terranova, Leonardo [VerfasserIn]
Oriano, Martina [VerfasserIn]
Contarini, Martina [VerfasserIn]
Blasi, Francesco [VerfasserIn]

Links:

Volltext

Themen:

Cystic fibrosis
Journal Article
Naïve patients
Observational Study
Pneumococcal Vaccines
Pneumococcal vaccine
Pneumococcus
Real-time PCR
Serotyping

Anmerkungen:

Date Completed 23.12.2021

Date Revised 23.12.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s10096-021-04263-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324910363