The effect of vitamin C supplementation on mood status in adults : a systematic review and meta-analysis of randomized controlled clinical trials
Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to clarify the effect of vitamin C supplementation on mood in both depressed and non-depressed populations.
METHODS: A systematic search of PubMed, EMBASE, ISI web of science and Scopus databases was conducted, from inception to 1 March 2020. Random-effects meta-analyses were used to estimate the effect size (as Hedge's g) of vitamin C supplementation on depressive symptoms.
RESULTS: Finding from 10 trials with 836 participants revealed no significant improvement in mood status in overall analysis (n = 10, Hedge's g = 0.09; 95% confidence interval: -0.15 to 0.33; P = 0.465). However, subgroup analysis showed beneficial effects of vitamin C supplementation in patients who were not prescribed antidepressants (subclinical depressed) (n = 5, Hedge's g: -0.18; 95% CI: -0.35, -0.01, P = 0.041; I2 = 0.00%,).
CONCLUSIONS: Although no significant effect on mood status was observed in overall population, this meta-analysis tentatively suggests that vitamin C may produce mood-elevating effects in patients with subclinical depression. Further research is recommended to reach a firm conclusion.
PROTOCOL REGISTRATION: The study protocol was registered in the international prospective register of systematic reviews database (http://www.crd.york.ac.uk/PROSPERO, registration no: CRD42018086677).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
|---|---|
| Enthalten in: |
General hospital psychiatry - 71(2021) vom: 15. Juli, Seite 36-42 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yosaee, Somaye [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antidepressant |
|---|
| Anmerkungen: |
Date Completed 30.12.2021 Date Revised 30.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.genhosppsych.2021.04.006 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM324858574 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM324858574 | ||
| 003 | DE-627 | ||
| 005 | 20231225191215.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.genhosppsych.2021.04.006 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1082.xml |
| 035 | |a (DE-627)NLM324858574 | ||
| 035 | |a (NLM)33932734 | ||
| 035 | |a (PII)S0163-8343(21)00056-6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yosaee, Somaye |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of vitamin C supplementation on mood status in adults |b a systematic review and meta-analysis of randomized controlled clinical trials |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.12.2021 | ||
| 500 | |a Date Revised 30.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to clarify the effect of vitamin C supplementation on mood in both depressed and non-depressed populations | ||
| 520 | |a METHODS: A systematic search of PubMed, EMBASE, ISI web of science and Scopus databases was conducted, from inception to 1 March 2020. Random-effects meta-analyses were used to estimate the effect size (as Hedge's g) of vitamin C supplementation on depressive symptoms | ||
| 520 | |a RESULTS: Finding from 10 trials with 836 participants revealed no significant improvement in mood status in overall analysis (n = 10, Hedge's g = 0.09; 95% confidence interval: -0.15 to 0.33; P = 0.465). However, subgroup analysis showed beneficial effects of vitamin C supplementation in patients who were not prescribed antidepressants (subclinical depressed) (n = 5, Hedge's g: -0.18; 95% CI: -0.35, -0.01, P = 0.041; I2 = 0.00%,) | ||
| 520 | |a CONCLUSIONS: Although no significant effect on mood status was observed in overall population, this meta-analysis tentatively suggests that vitamin C may produce mood-elevating effects in patients with subclinical depression. Further research is recommended to reach a firm conclusion | ||
| 520 | |a PROTOCOL REGISTRATION: The study protocol was registered in the international prospective register of systematic reviews database (http://www.crd.york.ac.uk/PROSPERO, registration no: CRD42018086677) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Antidepressant | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Mood | |
| 650 | 4 | |a Nutraceutical | |
| 650 | 4 | |a Vitamin C | |
| 650 | 7 | |a Ascorbic Acid |2 NLM | |
| 650 | 7 | |a PQ6CK8PD0R |2 NLM | |
| 700 | 1 | |a Keshtkaran, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Abdollahi, Shima |e verfasserin |4 aut | |
| 700 | 1 | |a Shidfar, Farzad |e verfasserin |4 aut | |
| 700 | 1 | |a Sarris, Jerome |e verfasserin |4 aut | |
| 700 | 1 | |a Soltani, Sepideh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t General hospital psychiatry |d 1987 |g 71(2021) vom: 15. Juli, Seite 36-42 |w (DE-627)NLM000421065 |x 1873-7714 |7 nnns |
| 773 | 1 | 8 | |g volume:71 |g year:2021 |g day:15 |g month:07 |g pages:36-42 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.genhosppsych.2021.04.006 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 71 |j 2021 |b 15 |c 07 |h 36-42 | ||