From Channels to Canonical Wnt Signaling : A Pathological Perspective

Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the membrane potential to modulation of intracellular pathways, in particular the influence of ion channels in Wnt signaling regulation has been widely investigated. This review will discuss the known links between ion channels and canonical Wnt signaling, focusing on their possible roles in human metabolic diseases, neurological disorders, and cancer.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

International journal of molecular sciences - 22(2021), 9 vom: 28. Apr.

Sprache:

Englisch

Beteiligte Personen:

Muccioli, Silvia [VerfasserIn]
Brillo, Valentina [VerfasserIn]
Chieregato, Leonardo [VerfasserIn]
Leanza, Luigi [VerfasserIn]
Checchetto, Vanessa [VerfasserIn]
Costa, Roberto [VerfasserIn]

Links:

Volltext

Themen:

Cancer
Ion Channels
Ion channels
Journal Article
Metabolic diseases
Neurological disorders
Review
Wnt signaling

Anmerkungen:

Date Completed 28.05.2021

Date Revised 28.05.2021

published: Electronic

Citation Status MEDLINE

doi:

10.3390/ijms22094613

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324780206