Chimeric Antigen Receptor T Cell Therapy : A Comprehensive Review of Clinical Efficacy, Toxicity, and Best Practices for Outpatient Administration
Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved..
Chimeric antigen receptor T cell (CAR T) therapy has been integrated into treatment algorithms for acute leukemia, lymphoma, and, most recently, multiple myeloma. The number of clinical trials in both hematologic and solid tumor malignancies for new products and potential indications continues to grow. The clinical toxicities of CAR T therapy include cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, which often warrant inpatient admission for close monitoring and treatment. Consequently, many centers have built processes around the administration of these cells in the inpatient setting. As new products gain Food and Drug Administration approval with more manageable toxicity profiles, and as institutions gain experience with the management of these toxicities, outpatient administration and monitoring should be expected. In addition, payor reimbursements for inpatient treatment have put the sustainability of inpatient CAR T therapy in jeopardy, especially for centers with a payor mix that includes a high proportion of Medicare patients. This has the serious potential to limit access to care. As the use of CAR T therapy continues to expand, changes in payment models, care settings, or both are needed to ensure the sustainability of safe, efficient, and cost-effective treatment. This review outlines the efficacy and toxicity of currently approved products, as well as best practices to optimize the management of CAR T cell therapy in the outpatient setting.
| Errataetall: |
CommentIn: Transplant Cell Ther. 2022 Sep;28(9):583-585. - PMID 35781100 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Transplantation and cellular therapy - 27(2021), 7 vom: 01. Juli, Seite 558-570 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alexander, Maurice [VerfasserIn] |
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| Links: |
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| Themen: |
CAR T cell |
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| Anmerkungen: |
Date Completed 15.07.2021 Date Revised 23.09.2022 published: Print-Electronic CommentIn: Transplant Cell Ther. 2022 Sep;28(9):583-585. - PMID 35781100 Citation Status MEDLINE |
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| doi: |
10.1016/j.jtct.2021.01.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 500 | |a CommentIn: Transplant Cell Ther. 2022 Sep;28(9):583-585. - PMID 35781100 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Chimeric antigen receptor T cell (CAR T) therapy has been integrated into treatment algorithms for acute leukemia, lymphoma, and, most recently, multiple myeloma. The number of clinical trials in both hematologic and solid tumor malignancies for new products and potential indications continues to grow. The clinical toxicities of CAR T therapy include cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, which often warrant inpatient admission for close monitoring and treatment. Consequently, many centers have built processes around the administration of these cells in the inpatient setting. As new products gain Food and Drug Administration approval with more manageable toxicity profiles, and as institutions gain experience with the management of these toxicities, outpatient administration and monitoring should be expected. In addition, payor reimbursements for inpatient treatment have put the sustainability of inpatient CAR T therapy in jeopardy, especially for centers with a payor mix that includes a high proportion of Medicare patients. This has the serious potential to limit access to care. As the use of CAR T therapy continues to expand, changes in payment models, care settings, or both are needed to ensure the sustainability of safe, efficient, and cost-effective treatment. This review outlines the efficacy and toxicity of currently approved products, as well as best practices to optimize the management of CAR T cell therapy in the outpatient setting | ||
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| 700 | 1 | |a Shaw, J Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Bachmeier, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Shigle, Terri Lynn |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmoudjafari, Zahra |e verfasserin |4 aut | |
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