CT-Guided 125I Brachytherapy in the Treatment of Hepatocellular Carcinoma Refractory to Conventional Transarterial Chemoembolization : A Pilot Study

© 2021 Xu et al..

PURPOSE: To investigate the efficacy and safety of CT-guided 125I brachytherapy in the treatment of hepatocellular carcinoma (HCC) refractory to conventional transarterial chemoembolization (TACE).

METHODS: Nineteen patients with TACE-refractory HCC treated with CT-guided 125I brachytherapy between June 2017 and June 2020 at Jiangyin People's Hospital were enrolled in this study. In addition, we used the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria to evaluate the treatment response after 125I brachytherapy.

RESULTS: Twenty-one tumours were treated with CT-guided 125I brachytherapy in nineteen patients. Twelve tumours (57.1%) showed a complete response, and a partial response was observed in seven tumours (33.3%). The six-month objective response rate was 90.5% (19/21). The adverse effects of CT-guided 125I brachytherapy were tolerable.

CONCLUSION: Our preliminary clinical experience demonstrated that CT-guided 125I brachytherapy was effective and well tolerated for the treatment of TACE-refractory HCC, suggesting that CT-guided 125I brachytherapy has the potential to become an effective alternative treatment for TACE-refractory HCC.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

Cancer management and research - 13(2021) vom: 30., Seite 3317-3326

Sprache:

Englisch

Beteiligte Personen:

Xu, Xinjian [VerfasserIn]
Ding, Yiwen [VerfasserIn]
Pan, Tianfan [VerfasserIn]
Gao, Feng [VerfasserIn]
Huang, Xiangzhong [VerfasserIn]
Sun, Qiulian [VerfasserIn]

Links:

Volltext

Themen:

125I brachytherapy
Hepatocellular carcinoma
Journal Article
Refractory
TACE

Anmerkungen:

Date Revised 11.11.2023

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.2147/CMAR.S305422

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324382618