The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
© 2021 Almasmoum..
Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncogenes, whereas others, such as MUC2 and MUC6, are tumor suppressors. However, there are still mucins with unidentified roles in CRC. In this review, we discuss the reported roles of mucins in CRC. Moreover, we review the capability of the mucin family to serve as a sensitive and specific histopathological marker for the early diagnosis of CRC. Lastly, the role of mucin genes clustered on chromosome 7q22 in CRC and other cancers is also discussed.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
---|---|
Enthalten in: |
Cancer management and research - 13(2021) vom: 30., Seite 3271-3280 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Almasmoum, Hussain [VerfasserIn] |
---|
Links: |
---|
Themen: |
Chromosome 7q22.1 |
---|
Anmerkungen: |
Date Revised 24.04.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.2147/CMAR.S299089 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM32438260X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM32438260X | ||
003 | DE-627 | ||
005 | 20231225190215.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2147/CMAR.S299089 |2 doi | |
028 | 5 | 2 | |a pubmed24n1081.xml |
035 | |a (DE-627)NLM32438260X | ||
035 | |a (NLM)33883940 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Almasmoum, Hussain |e verfasserin |4 aut | |
245 | 1 | 4 | |a The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 24.04.2021 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2021 Almasmoum. | ||
520 | |a Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncogenes, whereas others, such as MUC2 and MUC6, are tumor suppressors. However, there are still mucins with unidentified roles in CRC. In this review, we discuss the reported roles of mucins in CRC. Moreover, we review the capability of the mucin family to serve as a sensitive and specific histopathological marker for the early diagnosis of CRC. Lastly, the role of mucin genes clustered on chromosome 7q22 in CRC and other cancers is also discussed | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a MUC12 | |
650 | 4 | |a MUC17 | |
650 | 4 | |a MUC3 | |
650 | 4 | |a chromosome 7q22.1 | |
650 | 4 | |a colorectal cancer | |
650 | 4 | |a mucins | |
773 | 0 | 8 | |i Enthalten in |t Cancer management and research |d 2009 |g 13(2021) vom: 30., Seite 3271-3280 |w (DE-627)NLM197692605 |x 1179-1322 |7 nnns |
773 | 1 | 8 | |g volume:13 |g year:2021 |g day:30 |g pages:3271-3280 |
856 | 4 | 0 | |u http://dx.doi.org/10.2147/CMAR.S299089 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 13 |j 2021 |b 30 |h 3271-3280 |