Retentive efficacy, antimicrobial and cytotoxicity comparisons between different types of commercial and experimental denture adhesives with antifungal action

The effect of the addition of nystatin and an alternative antifungal derived from pyrazoles in different commercial denture adhesives on their retentive efficacy, cytotoxicity and antimicrobial activity against Candida albicans was evaluated. Commercial denture adhesives were prepared with the inclusion of nystatin and 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamide (pyrazole) in three concentrations: 23.78 %w/w, 3.02 %w/w, and 0.31 %w/w (0.015 g, 0.0015 g, and 0.00015 g, respectively). The retentive efficacy was tested observing the influence of the medium, type of commercial denture type and the test condition (dipping). The antifungal action through disk diffusion and direct contact tests at 1, 4, 8 and 12 h and cytotoxic activity was evaluated in mouse fibroblasts (NIH/3T3) by the MTT reduction colorimetric assay. The addition of pyrazole and nystatin in commercial denture adhesives did not affect retentive efficacy rates and enhanced antifungal actions against Candida albicans. Results show a possibility of using denture adhesives as a delivery system for commercial antifungals (Nystatin) or pyrazole, with the second concentration (1,560 µg-3.02 %w/w) as the most efficient.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

Dental materials journal - 40(2021), 4 vom: 31. Juli, Seite 1055-1062

Sprache:

Englisch

Beteiligte Personen:

Oliveira, Simone Gomes Dias de [VerfasserIn]
Martos, Josué [VerfasserIn]
Carvalho, Rodrigo Varella de [VerfasserIn]
Pereira, Cláudio Martin Pereira de [VerfasserIn]
Lund, Rafael Guerra [VerfasserIn]
Piva, Evandro [VerfasserIn]

Links:

Volltext

Themen:

Anti-Bacterial Agents
Antifungal Agents
Antifungal agents
Denture adhesives
Disk diffusion antimicrobial tests
Journal Article
Pyrazoles
Toxicity tests

Anmerkungen:

Date Completed 03.08.2021

Date Revised 03.08.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.4012/dmj.2020-262

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324376510