Comparison of diuretic strategies in diuretic-resistant acute heart failure : a systematic review and network meta-analysis

OBJECTIVE: Up to 50% of patients hospitalized for acute heart failure (AHF) show resistance to diuretics. This condition contributes to a prolonged hospital length of stay and a higher risk of death. This review aimed to investigate whether a diuretic therapeutic approach more effective than furosemide alone exists for patients with diuretic-resistant AHF.

MATERIALS AND METHODS: We identified all randomized controlled trials (RCTs) evaluating diuretic therapy in patients with diuretic-resistant AHF. We searched Pubmed, BioMed Central, and Cochrane CENTRAL databases.

RESULTS: Six RCTs were identified, involving a total of 845 patients. The P-score ranges from 0.6663 for furosemide to 0.2294 for the tolvaptan-furosemide. We found no significant differences in efficacy for any drug comparison.

CONCLUSIONS: None of the diuretics considered in RCTs performed to date (tolvaptan, metolazone, hydrochlorothiazide, indapamide) appear to be more effective than furosemide therapy alone for the treatment of patients with diuretic-resistant AHF.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:25

Enthalten in:

European review for medical and pharmacological sciences - 25(2021), 7 vom: 20. Apr., Seite 2971-2980

Sprache:

Englisch

Beteiligte Personen:

Orso, D [VerfasserIn]
Tavazzi, G [VerfasserIn]
Corradi, F [VerfasserIn]
Mearelli, F [VerfasserIn]
Federici, N [VerfasserIn]
Peric, D [VerfasserIn]
D'Andrea, N [VerfasserIn]
Santori, G [VerfasserIn]
Mojoli, F [VerfasserIn]
Forfori, F [VerfasserIn]
Vetrugno, L [VerfasserIn]
Bove, T [VerfasserIn]

Links:

Volltext

Themen:

Carbonic Anhydrase Inhibitors
Comparative Study
Diuretics
Journal Article
Meta-Analysis
Systematic Review

Anmerkungen:

Date Completed 06.01.2022

Date Revised 06.01.2022

published: Print

Citation Status MEDLINE

doi:

10.26355/eurrev_202104_25550

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM324321058