Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals
Copyright © 2021 Elsevier Ltd. All rights reserved..
Host-microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that coordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
|---|---|
| Enthalten in: |
Trends in molecular medicine - 27(2021), 7 vom: 14. Juli, Seite 624-626 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Guan, Xiao-Jing [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 27.12.2021 Date Revised 27.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.molmed.2021.03.007 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM324203934 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM324203934 | ||
| 003 | DE-627 | ||
| 005 | 20231225185821.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molmed.2021.03.007 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1080.xml |
| 035 | |a (DE-627)NLM324203934 | ||
| 035 | |a (NLM)33865719 | ||
| 035 | |a (PII)S1471-4914(21)00092-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Guan, Xiao-Jing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.12.2021 | ||
| 500 | |a Date Revised 27.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Host-microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that coordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a drug discovery | |
| 650 | 4 | |a host–microbe interaction | |
| 650 | 4 | |a microbial metabolite | |
| 650 | 4 | |a nuclear receptors | |
| 650 | 4 | |a target identification | |
| 650 | 7 | |a Receptors, Cytoplasmic and Nuclear |2 NLM | |
| 650 | 7 | |a Small Molecule Libraries |2 NLM | |
| 700 | 1 | |a Zhang, You-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Hai-Ping |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in molecular medicine |d 2001 |g 27(2021), 7 vom: 14. Juli, Seite 624-626 |w (DE-627)NLM111960800 |x 1471-499X |7 nnns |
| 773 | 1 | 8 | |g volume:27 |g year:2021 |g number:7 |g day:14 |g month:07 |g pages:624-626 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.molmed.2021.03.007 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 27 |j 2021 |e 7 |b 14 |c 07 |h 624-626 | ||