GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke
Copyright © 2021. Published by Elsevier Inc..
The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury. In the central nervous system, GPR37 is enriched in mature oligodendrocytes, but following injury we have found that its expression is dramatically increased within a population of Sox2-positive progenitor cells. Moreover, the genetic deletion of GPR37 did not alter the number of mature oligodendrocytes following injury but did markedly increase the number of both progenitor cells and injury-induced Olig2-expressing glia. Alterations in the glial environment were further evidenced by the decreased activation of oligodendrocyte precursor cells. These data reveal that GPR37 regulates the response of progenitor cells to ischemic injury and provides new perspectives into the potential for manipulating endogenous progenitor cells following stroke.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:342 |
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Enthalten in: |
Experimental neurology - 342(2021) vom: 15. Aug., Seite 113719 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Owino, Sharon [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 11.10.2021 Date Revised 10.01.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.expneurol.2021.113719 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM323942164 |
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520 | |a Copyright © 2021. Published by Elsevier Inc. | ||
520 | |a The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury. In the central nervous system, GPR37 is enriched in mature oligodendrocytes, but following injury we have found that its expression is dramatically increased within a population of Sox2-positive progenitor cells. Moreover, the genetic deletion of GPR37 did not alter the number of mature oligodendrocytes following injury but did markedly increase the number of both progenitor cells and injury-induced Olig2-expressing glia. Alterations in the glial environment were further evidenced by the decreased activation of oligodendrocyte precursor cells. These data reveal that GPR37 regulates the response of progenitor cells to ischemic injury and provides new perspectives into the potential for manipulating endogenous progenitor cells following stroke | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a GPR37 | |
650 | 4 | |a Gliosis | |
650 | 4 | |a Ischemic injury | |
650 | 4 | |a Progenitor cells | |
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700 | 1 | |a Giddens, Michelle M |e verfasserin |4 aut | |
700 | 1 | |a Jiang, Jessie G |e verfasserin |4 aut | |
700 | 1 | |a Nguyen, TrangKimberly T |e verfasserin |4 aut | |
700 | 1 | |a Shiu, Fu Hung |e verfasserin |4 aut | |
700 | 1 | |a Lala, Trisha |e verfasserin |4 aut | |
700 | 1 | |a Gearing, Marla |e verfasserin |4 aut | |
700 | 1 | |a McCrary, Myles R |e verfasserin |4 aut | |
700 | 1 | |a Gu, Xiaohuan |e verfasserin |4 aut | |
700 | 1 | |a Wei, Ling |e verfasserin |4 aut | |
700 | 1 | |a Yu, Shan P |e verfasserin |4 aut | |
700 | 1 | |a Hall, Randy A |e verfasserin |4 aut | |
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