Temporal Variation in Staphylococcus aureus Protein A Genotypes from Nose and Skin in Atopic Dermatitis Patients
© 2021 The Author(s) Published by S. Karger AG, Basel..
BACKGROUND: Staphylococcus aureus colonization is associated with disease severity in patients with atopic dermatitis (AD).
OBJECTIVE: To investigate temporal variation in S. aureus protein A gene (spa)-types isolated from the nose and lesional skin and the correlation of spa-types with disease severity.
RESULTS: This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different spa-types were detected in the nose and skin cultures. Seventy-three patients were colonized with S. aureus in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical spa-types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical spa-types over time. The same spa-type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific spa-types or with temporal variation in spa-type.
CONCLUSION: S. aureus strains in AD are highly heterogeneous between patients. The majority of patients carry the same spa-type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant spa-type or temporal variation is associated with increased disease severity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:237 |
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| Enthalten in: |
Dermatology (Basel, Switzerland) - 237(2021), 4 vom: 01., Seite 506-512 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Mierlo, Minke M F [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Inflammatory Agents |
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| Anmerkungen: |
Date Completed 14.12.2021 Date Revised 14.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000515235 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323788254 |
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| 245 | 1 | 0 | |a Temporal Variation in Staphylococcus aureus Protein A Genotypes from Nose and Skin in Atopic Dermatitis Patients |
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| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The Author(s) Published by S. Karger AG, Basel. | ||
| 520 | |a BACKGROUND: Staphylococcus aureus colonization is associated with disease severity in patients with atopic dermatitis (AD) | ||
| 520 | |a OBJECTIVE: To investigate temporal variation in S. aureus protein A gene (spa)-types isolated from the nose and lesional skin and the correlation of spa-types with disease severity | ||
| 520 | |a RESULTS: This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different spa-types were detected in the nose and skin cultures. Seventy-three patients were colonized with S. aureus in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical spa-types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical spa-types over time. The same spa-type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific spa-types or with temporal variation in spa-type | ||
| 520 | |a CONCLUSION: S. aureus strains in AD are highly heterogeneous between patients. The majority of patients carry the same spa-type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant spa-type or temporal variation is associated with increased disease severity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Atopic dermatitis | |
| 650 | 4 | |a Eczema | |
| 650 | 4 | |a Microbiome | |
| 650 | 4 | |a Staphylococcus aureus | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Staphylococcal Protein A |2 NLM | |
| 650 | 7 | |a Triamcinolone Acetonide |2 NLM | |
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| 700 | 1 | |a Totté, Joan E E |e verfasserin |4 aut | |
| 700 | 1 | |a de Wit, Jill |e verfasserin |4 aut | |
| 700 | 1 | |a Herpers, Bjorn L |e verfasserin |4 aut | |
| 700 | 1 | |a Vos, Margreet C |e verfasserin |4 aut | |
| 700 | 1 | |a Klaassen, Corné H W |e verfasserin |4 aut | |
| 700 | 1 | |a Pardo, Luba M |e verfasserin |4 aut | |
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