Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction and Other Cellular Functions

Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of cytosine to uracil on single-stranded DNA or/and RNA. APOBEC proteins are involved in diverse biological functions, including adaptive and innate immunity, which are critical for restricting viral infection and endogenous retroelements. Dysregulation of their functions can cause undesired genomic mutations and RNA modification, leading to various associated diseases, such as hyper-IgM syndrome and cancer. This review focuses on the structural and biochemical data on the multimerization status of individual APOBECs and the associated functional implications. Many APOBECs form various multimeric complexes, and multimerization is an important way to regulate functions for some of these proteins at several levels, such as deaminase activity, protein stability, subcellular localization, protein storage and activation, virion packaging, and antiviral activity. The multimerization of some APOBECs is more complicated than others, due to the associated complex RNA binding modes.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

Viruses - 13(2021), 3 vom: 17. März

Sprache:

Englisch

Beteiligte Personen:

Chen, Xiaojiang S [VerfasserIn]

Links:

Volltext

Themen:

APOBEC Deaminases
EC 3.5.4.5
Innate and acquired immunity
Journal Article
Multimerization or oligomerization
Mutation and cancer
Research Support, N.I.H., Extramural
Review
Structure
Viral restriction

Anmerkungen:

Date Completed 24.08.2021

Date Revised 04.03.2022

published: Electronic

Citation Status MEDLINE

doi:

10.3390/v13030497

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM323584330