Cognitive dysfunction among people with systemic lupus erythematosus is associated with reduced participation in daily life
OBJECTIVES: This study aimed to investigate the distribution of cognitive function in people with systemic lupus erythematosus (SLE) by objective and self-report measures and associations between cognition and participation among people with SLE.
METHODS: Fifty-five volunteers with SLE (age: 39.7 ± 12.7yrs, female: 92.7%) completed the Montreal Cognitive Assessment (MoCA) to measure cognitive ability objectively, the Cognitive Symptom Inventory (CSI) and PROMIS Cognitive Function 8a (CF) to assess self-reported everyday cognition, and PROMIS-43 Profile to assess self-reported ability to participate in social roles and activities (participation) and other disease-associated symptoms (e.g., depression, pain, fatigue).
RESULTS: The average MoCA score was 25.3 ± 3.1, with 47.3% of participants scoring <26, which is indicative of cognitive impairment. Group average CSI (35.8 ± 7.9), CF (T-score = 45.0 ± 8.5), and participation (T-score = 46.9 ± 11.2) scores suggest mildly impaired functional cognition and participation compared to normative data. Participation correlated with self-reported everyday cognition measures (r ≥ 0.56, p < 0.01) but not with MoCA (r = 0.25, p = 0.06). In hierarchical linear regression analysis, CSI, fatigue, and pain were each significant independent predictors of participation (R2 = 0.78, p < 0.01).
CONCLUSIONS: We found that cognitive dysfunction is common among people with SLE. Along with pain and fatigue, reduced everyday cognitive function contributes to reduced participation in social, leisure, work, and family-related activities.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
Lupus - 30(2021), 7 vom: 15. Juni, Seite 1100-1107 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kim, Moon Young [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cognitive dysfunction |
|---|
| Anmerkungen: |
Date Completed 03.11.2021 Date Revised 25.02.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1177/09612033211006187 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM323502164 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM323502164 | ||
| 003 | DE-627 | ||
| 005 | 20231225184324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/09612033211006187 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1078.xml |
| 035 | |a (DE-627)NLM323502164 | ||
| 035 | |a (NLM)33794707 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kim, Moon Young |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cognitive dysfunction among people with systemic lupus erythematosus is associated with reduced participation in daily life |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 03.11.2021 | ||
| 500 | |a Date Revised 25.02.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: This study aimed to investigate the distribution of cognitive function in people with systemic lupus erythematosus (SLE) by objective and self-report measures and associations between cognition and participation among people with SLE | ||
| 520 | |a METHODS: Fifty-five volunteers with SLE (age: 39.7 ± 12.7yrs, female: 92.7%) completed the Montreal Cognitive Assessment (MoCA) to measure cognitive ability objectively, the Cognitive Symptom Inventory (CSI) and PROMIS Cognitive Function 8a (CF) to assess self-reported everyday cognition, and PROMIS-43 Profile to assess self-reported ability to participate in social roles and activities (participation) and other disease-associated symptoms (e.g., depression, pain, fatigue) | ||
| 520 | |a RESULTS: The average MoCA score was 25.3 ± 3.1, with 47.3% of participants scoring <26, which is indicative of cognitive impairment. Group average CSI (35.8 ± 7.9), CF (T-score = 45.0 ± 8.5), and participation (T-score = 46.9 ± 11.2) scores suggest mildly impaired functional cognition and participation compared to normative data. Participation correlated with self-reported everyday cognition measures (r ≥ 0.56, p < 0.01) but not with MoCA (r = 0.25, p = 0.06). In hierarchical linear regression analysis, CSI, fatigue, and pain were each significant independent predictors of participation (R2 = 0.78, p < 0.01) | ||
| 520 | |a CONCLUSIONS: We found that cognitive dysfunction is common among people with SLE. Along with pain and fatigue, reduced everyday cognitive function contributes to reduced participation in social, leisure, work, and family-related activities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Systemic lupus erythematosus | |
| 650 | 4 | |a cognitive dysfunction | |
| 650 | 4 | |a participation | |
| 700 | 1 | |a Sen, Deepali |e verfasserin |4 aut | |
| 700 | 1 | |a Drummond, Ronald R |e verfasserin |4 aut | |
| 700 | 1 | |a Brandenburg, Matthew C |e verfasserin |4 aut | |
| 700 | 1 | |a Biesanz, Kathryn Lp |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Alfred Hj |e verfasserin |4 aut | |
| 700 | 1 | |a Eisen, Seth A |e verfasserin |4 aut | |
| 700 | 1 | |a Baum, Carolyn M |e verfasserin |4 aut | |
| 700 | 1 | |a Foster, Erin R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Lupus |d 1991 |g 30(2021), 7 vom: 15. Juni, Seite 1100-1107 |w (DE-627)NLM012651214 |x 1477-0962 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2021 |g number:7 |g day:15 |g month:06 |g pages:1100-1107 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/09612033211006187 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 2021 |e 7 |b 15 |c 06 |h 1100-1107 | ||