Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
Vagus nerve stimulation (VNS) is thought to affect neural activity by recruiting brain-wide release of neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly being explored for other disorders, such as depression, and as a cognitive enhancer. However, the promise of VNS is only partially fulfilled due to a lack of mechanistic understanding of the transfer function between stimulation parameters and neuromodulatory response, together with a lack of biosensors for assaying stimulation efficacy in real time. We here develop an approach to VNS in head-fixed mice on a treadmill and show that pupil dilation is a reliable and convenient biosensor for VNS-evoked cortical neuromodulation. In an 'optimal' zone of stimulation parameters, current leakage and off-target effects are minimized and the extent of pupil dilation tracks VNS-evoked basal-forebrain cholinergic axon activity in neocortex. Thus, pupil dilation is a sensitive readout of the moment-by-moment, titratable effects of VNS on brain state.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Nature communications - 12(2021), 1 vom: 09. März, Seite 1539 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mridha, Zakir [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 05.04.2021 Date Revised 31.03.2024 published: Electronic figshare: 10.6084/m9.figshare.12899375 Citation Status MEDLINE |
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| doi: |
10.1038/s41467-021-21730-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323071287 |
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| 245 | 1 | 0 | |a Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve |
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| 500 | |a Date Revised 31.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a figshare: 10.6084/m9.figshare.12899375 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Vagus nerve stimulation (VNS) is thought to affect neural activity by recruiting brain-wide release of neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly being explored for other disorders, such as depression, and as a cognitive enhancer. However, the promise of VNS is only partially fulfilled due to a lack of mechanistic understanding of the transfer function between stimulation parameters and neuromodulatory response, together with a lack of biosensors for assaying stimulation efficacy in real time. We here develop an approach to VNS in head-fixed mice on a treadmill and show that pupil dilation is a reliable and convenient biosensor for VNS-evoked cortical neuromodulation. In an 'optimal' zone of stimulation parameters, current leakage and off-target effects are minimized and the extent of pupil dilation tracks VNS-evoked basal-forebrain cholinergic axon activity in neocortex. Thus, pupil dilation is a sensitive readout of the moment-by-moment, titratable effects of VNS on brain state | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a de Gee, Jan Willem |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Yanchen |e verfasserin |4 aut | |
| 700 | 1 | |a Alkashgari, Rayan |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Suminski, Aaron |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Matthew P |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wenhao |e verfasserin |4 aut | |
| 700 | 1 | |a McGinley, Matthew James |e verfasserin |4 aut | |
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