circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway

© 2021 Wiley Periodicals LLC..

Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR-7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR-7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:236

Enthalten in:

Journal of cellular physiology - 236(2021), 10 vom: 30. Okt., Seite 6793-6805

Sprache:

Englisch

Beteiligte Personen:

Gao, Mengjin [VerfasserIn]
Li, Xue [VerfasserIn]
Yang, Zuojun [VerfasserIn]
Zhao, Shuo [VerfasserIn]
Ling, Xingxing [VerfasserIn]
Li, Jingjing [VerfasserIn]
Xing, Kai [VerfasserIn]
Qi, Xiaolong [VerfasserIn]
Wang, Xiangguo [VerfasserIn]
Xiao, Longfei [VerfasserIn]
Ni, Hemin [VerfasserIn]
Guo, Yong [VerfasserIn]
Sheng, Xihui [VerfasserIn]

Links:

Volltext

Themen:

Basic Helix-Loop-Helix Transcription Factors
CircHIPK3
Journal Article
MIRN7 microRNA, mouse
MiR-7
MicroRNAs
Myoblast proliferation and differentiation
RNA, Circular
Research Support, Non-U.S. Gov't
Skeletal muscle development
TCF12
Tcf12 protein, mouse

Anmerkungen:

Date Completed 29.11.2021

Date Revised 29.11.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/jcp.30363

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM323053769