circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway
© 2021 Wiley Periodicals LLC..
Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR-7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR-7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:236 |
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Enthalten in: |
Journal of cellular physiology - 236(2021), 10 vom: 30. Okt., Seite 6793-6805 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gao, Mengjin [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 29.11.2021 Date Revised 29.11.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/jcp.30363 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM323053769 |
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520 | |a Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR-7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR-7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a TCF12 | |
650 | 4 | |a circHIPK3 | |
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650 | 4 | |a skeletal muscle development | |
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650 | 7 | |a MIRN7 microRNA, mouse |2 NLM | |
650 | 7 | |a MicroRNAs |2 NLM | |
650 | 7 | |a RNA, Circular |2 NLM | |
650 | 7 | |a Tcf12 protein, mouse |2 NLM | |
700 | 1 | |a Li, Xue |e verfasserin |4 aut | |
700 | 1 | |a Yang, Zuojun |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Shuo |e verfasserin |4 aut | |
700 | 1 | |a Ling, Xingxing |e verfasserin |4 aut | |
700 | 1 | |a Li, Jingjing |e verfasserin |4 aut | |
700 | 1 | |a Xing, Kai |e verfasserin |4 aut | |
700 | 1 | |a Qi, Xiaolong |e verfasserin |4 aut | |
700 | 1 | |a Wang, Xiangguo |e verfasserin |4 aut | |
700 | 1 | |a Xiao, Longfei |e verfasserin |4 aut | |
700 | 1 | |a Ni, Hemin |e verfasserin |4 aut | |
700 | 1 | |a Guo, Yong |e verfasserin |4 aut | |
700 | 1 | |a Sheng, Xihui |e verfasserin |4 aut | |
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