Molecular and computational approaches to map regulatory elements in 3D chromatin structure
Epigenetic marks do not change the sequence of DNA but affect gene expression in a cell-type specific manner by altering the activities of regulatory elements. Development of new molecular biology assays, sequencing technologies, and computational approaches enables us to profile the human epigenome in three-dimensional structure genome-wide. Here we describe various molecular biology techniques and bioinformatic tools that have been developed to measure the activities of regulatory elements and their chromatin interactions. Moreover, we list currently available three-dimensional epigenomic data sets that are generated in various human cell types and tissues to assist in the design and analysis of research projects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Epigenetics & chromatin - 14(2021), 1 vom: 19. März, Seite 14 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Beoung Hun [VerfasserIn] |
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| Links: |
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| Themen: |
Analysis tools |
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| Anmerkungen: |
Date Completed 13.01.2022 Date Revised 31.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s13072-021-00390-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM322974828 |
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| 520 | |a Epigenetic marks do not change the sequence of DNA but affect gene expression in a cell-type specific manner by altering the activities of regulatory elements. Development of new molecular biology assays, sequencing technologies, and computational approaches enables us to profile the human epigenome in three-dimensional structure genome-wide. Here we describe various molecular biology techniques and bioinformatic tools that have been developed to measure the activities of regulatory elements and their chromatin interactions. Moreover, we list currently available three-dimensional epigenomic data sets that are generated in various human cell types and tissues to assist in the design and analysis of research projects | ||
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