Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats
There is no effective treatment to halt peripheral nervous system damage in diabetic peripheral neuropathy. Mitochondria have been at the center of discussions as important factors in the development of neuropathy in diabetes. Photobiomodulation has been gaining clinical acceptance as it shows beneficial effects on a variety of nervous system disorders. In this study, the effects of photobiomodulation (904 nm, 45 mW, 6.23 J/cm2, 0.13 cm2, 60 ns pulsed time) on mitochondrial dynamics were evaluated in an adult male rat experimental model of streptozotocin-induced type 1 diabetes. Results presented here indicate that photobiomodulation could have an important role in preventing or reversing mitochondrial dynamics dysfunction in the course of peripheral nervous system damage in diabetic peripheral neuropathy. Photobiomodulation showed its effects on modulating the protein expression of mitofusin 2 and dynamin-related protein 1 in the sciatic nerve and in the dorsal root ganglia neurons of streptozotocin-induced type 1 diabetes in rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology - 20(2021), 2 vom: 15. Feb., Seite 293-301 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rocha, Igor Rafael Correia [VerfasserIn] |
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| Links: |
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| Themen: |
5W494URQ81 |
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| Anmerkungen: |
Date Completed 12.07.2021 Date Revised 12.07.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s43630-021-00018-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322779723 |
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| 100 | 1 | |a Rocha, Igor Rafael Correia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a There is no effective treatment to halt peripheral nervous system damage in diabetic peripheral neuropathy. Mitochondria have been at the center of discussions as important factors in the development of neuropathy in diabetes. Photobiomodulation has been gaining clinical acceptance as it shows beneficial effects on a variety of nervous system disorders. In this study, the effects of photobiomodulation (904 nm, 45 mW, 6.23 J/cm2, 0.13 cm2, 60 ns pulsed time) on mitochondrial dynamics were evaluated in an adult male rat experimental model of streptozotocin-induced type 1 diabetes. Results presented here indicate that photobiomodulation could have an important role in preventing or reversing mitochondrial dynamics dysfunction in the course of peripheral nervous system damage in diabetic peripheral neuropathy. Photobiomodulation showed its effects on modulating the protein expression of mitofusin 2 and dynamin-related protein 1 in the sciatic nerve and in the dorsal root ganglia neurons of streptozotocin-induced type 1 diabetes in rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dorsal root ganglia | |
| 650 | 4 | |a Dynamin-related protein 1 | |
| 650 | 4 | |a Laser therapy | |
| 650 | 4 | |a Mitofusin-2 | |
| 650 | 4 | |a Sciatic nerve | |
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| 700 | 1 | |a Perez-Reyes, Edward |e verfasserin |4 aut | |
| 700 | 1 | |a Chacur, Marucia |e verfasserin |4 aut | |
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