Magnetic resonance-guided laser interstitial thermal therapy : Correlations with seizure outcome
© 2021 International League Against Epilepsy..
OBJECTIVE: This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS).
METHODS: We identified 56 patients with magnetic resonance imaging-defined MTS who underwent MRgLiTT with at least 1 year of follow-up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to bilateral tonic-clonic seizures, duration of epilepsy at the time of surgery, frequency of interictal epileptiform discharges (IEDs), seizure frequency, and presence of bilateral IEDs.
RESULTS: Thirty-five (62.5%) patients were seizure-free at 1 year. The presence of bilateral IEDs and age at surgery were associated with 1-year seizure freedom after MRgLiTT. The presence of bilateral IEDS was associated with lower odds of seizure freedom (odds ratio [OR] = .05, 95% confidence interval [CI] = .01-.46, p = .008), whereas increasing age at surgery was associated with increased odds of seizure freedom (OR = 1.10, 95% CI = 1.03-1.19, p = .009).
SIGNIFICANCE: This study demonstrates associations between presence of bilateral IEDs and age at surgery and seizure freedom at 1 year after MRgLiTT.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Epilepsia - 62(2021), 5 vom: 04. Mai, Seite 1085-1091 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kang, Joon Y [VerfasserIn] |
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| Links: |
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| Themen: |
Epilepsy surgery |
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| Anmerkungen: |
Date Completed 30.09.2021 Date Revised 15.04.2022 published: Print-Electronic CommentIn: Epilepsia. 2021 Oct;62(10):2567. - PMID 34350989 Citation Status MEDLINE |
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| doi: |
10.1111/epi.16872 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322702402 |
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| 500 | |a Date Completed 30.09.2021 | ||
| 500 | |a Date Revised 15.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Epilepsia. 2021 Oct;62(10):2567. - PMID 34350989 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 International League Against Epilepsy. | ||
| 520 | |a OBJECTIVE: This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS) | ||
| 520 | |a METHODS: We identified 56 patients with magnetic resonance imaging-defined MTS who underwent MRgLiTT with at least 1 year of follow-up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to bilateral tonic-clonic seizures, duration of epilepsy at the time of surgery, frequency of interictal epileptiform discharges (IEDs), seizure frequency, and presence of bilateral IEDs | ||
| 520 | |a RESULTS: Thirty-five (62.5%) patients were seizure-free at 1 year. The presence of bilateral IEDs and age at surgery were associated with 1-year seizure freedom after MRgLiTT. The presence of bilateral IEDS was associated with lower odds of seizure freedom (odds ratio [OR] = .05, 95% confidence interval [CI] = .01-.46, p = .008), whereas increasing age at surgery was associated with increased odds of seizure freedom (OR = 1.10, 95% CI = 1.03-1.19, p = .009) | ||
| 520 | |a SIGNIFICANCE: This study demonstrates associations between presence of bilateral IEDs and age at surgery and seizure freedom at 1 year after MRgLiTT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a MR-guided LiTT | |
| 650 | 4 | |a epilepsy surgery | |
| 650 | 4 | |a hippocampal sclerosis | |
| 650 | 4 | |a mesial temporal sclerosis | |
| 650 | 4 | |a surgery outcomes | |
| 700 | 1 | |a Pickard, Allyson A |e verfasserin |4 aut | |
| 700 | 1 | |a Bronder, Jay |e verfasserin |4 aut | |
| 700 | 1 | |a Yenokyan, Gayane |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Mo |e verfasserin |4 aut | |
| 700 | 1 | |a Anderson, William S |e verfasserin |4 aut | |
| 700 | 1 | |a Sperling, Michael R |e verfasserin |4 aut | |
| 700 | 1 | |a Nei, Maromi |e verfasserin |4 aut | |
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