Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

Copyright © 2021 Liu, Zhang and Li..

Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) in many developed and developing countries. Pyroptosis is a recently discovered form of programmed cell death (PCD). With progress in research on DKD, researchers have become increasingly interested in elucidating the role of pyroptosis in DKD pathogenesis. This review focuses on the three pathways of pyroptosis generation: the canonical inflammasome, non-canonical inflammasome, and caspase-3-mediated inflammasome pathways. The molecular and pathophysiological mechanisms of the pyroptosis-related inflammasome pathway in the development of DKD are summarized. Activation of the diabetes-mediated pyroptosis-related inflammasomes, such as nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), Toll-like receptor 4 (TLR4), caspase-1, interleukin (IL)-1β, and the IL-18 axis, plays an essential role in DKD lesions. By inhibiting activation of the TLR4 and NLRP3 inflammasomes, the production of caspase-1, IL-1β, and IL-18 is inhibited, thereby improving the pathological changes associated with DKD. Studies using high-glucose-induced cell models, high-fat diet/streptozotocin-induced DKD animal models, and human biopsies will help determine the spatial and temporal expression of DKD inflammatory components. Recent studies have confirmed the relationship between the pyroptosis-related inflammasome pathway and kidney disease. However, these studies are relatively superficial at present, and the mechanism needs further elucidation. Linking these findings with disease activity and prognosis would provide new ideas for DKD research.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Frontiers in immunology - 12(2021) vom: 27., Seite 603416

Sprache:

Englisch

Beteiligte Personen:

Liu, Pan [VerfasserIn]
Zhang, Zhengdong [VerfasserIn]
Li, Yao [VerfasserIn]

Links:

Volltext

Themen:

Caspase 1
Cytokines
Diabetic kidney disease
EC 3.4.22.36
Inflammasome pathway
Inflammasomes
Journal Article
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human
Pathogenesis
Pyroptosis-related
Research Support, Non-U.S. Gov't
Review
TLR4 protein, human
Targeted inhibition
Toll-Like Receptor 4

Anmerkungen:

Date Completed 23.06.2021

Date Revised 23.06.2021

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.3389/fimmu.2021.603416

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM322498678