Displaced Object Recognition Memory in Rats
Copyright © 2019 The Authors; exclusive licensee Bio-protocol LLC..
The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to explore the objects. Following a delay period, the subject returns to the arena, but one of the previous objects has been moved to a new location. Greater exploration of the displaced object is used as the index of memory for the previous object location. An advantage of the DOR task is that subjects can be tested without explicit training, since this task exploits the natural tendency to be more interested in something novel. The spontaneous aspect of this task allows for the testing of animals as well as human populations that are unable to follow verbal instructions, such as babies. Therefore, this powerful test of recognition memory can be administered similarly for many species, including rats and humans, allowing for better translatability.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Bio-protocol - 9(2019), 8 vom: 20. Apr., Seite e3212 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mclagan, Ali N [VerfasserIn] |
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| Links: |
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| Themen: |
Behavior |
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| Anmerkungen: |
Date Revised 10.02.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.21769/BioProtoc.3212 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM322125006 |
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| 520 | |a The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to explore the objects. Following a delay period, the subject returns to the arena, but one of the previous objects has been moved to a new location. Greater exploration of the displaced object is used as the index of memory for the previous object location. An advantage of the DOR task is that subjects can be tested without explicit training, since this task exploits the natural tendency to be more interested in something novel. The spontaneous aspect of this task allows for the testing of animals as well as human populations that are unable to follow verbal instructions, such as babies. Therefore, this powerful test of recognition memory can be administered similarly for many species, including rats and humans, allowing for better translatability | ||
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