Epidemiological, clinical and biological profile of neuromeningeal cryptococcosis among people living with HIV in Kinshasa, Democratic Republic of Congo

Copyright: Bive Zono et al..

Neuromeningeal cryptococcosis (NMC) is one of the most frequent opportunistic infections (OI) in Human Immunodeficiency Virus (HIV) infection. In Kinshasa, the latest data on cryptococcosis were published in 1996. The objective was to describe the epidemiological, clinical and biological profiles of NMC in HIV-infected people living in Kinshasa. This is a descriptive study based on the medical records of patients who attended three clinics in Kinshasa between January 1 s t 2011 and December 31st 2014. Only the medical records of HIV-infected people presenting the NMC were reviewed. During the 4 year-period of the study, 261 HIV-positive patients presented to the clinics for neuromeningeal syndrome, including 23 with NMC. The global prevalence of NMC was 8.8% for the three clinics. The mean age was 42.8 ± 9.5 years, with male predominance (65.2%). The main symptoms were headache (73.9%), neck stiffness (60.9%), fever (47.8%), and coma (47.8%). Biological records were as follows: median CD4 cell count was 79 cells/mm3; cerebrospinal fluid (CSF) was clear for 56.5% of the cases with predominance of neutrophils in 73.9%. The outcome was fatal in 34.8% of cases. The prevalence and therapeutic outcome of NMC show that it constitutes a non-negligible OI in Kinshasa, especially in HIV-infected people at the AIDS stage. As HIV-infected people with severe immunosuppression are the most affected by NMC, active preventive measures should benefit this vulnerable category of people.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:37

Enthalten in:

The Pan African medical journal - 37(2020) vom: 15., Seite 302

Sprache:

Englisch

Beteiligte Personen:

Zono, Bive [VerfasserIn]
Kamangu, Erick [VerfasserIn]
Situakibanza, Hippolyte [VerfasserIn]
Amaela, Evelyne [VerfasserIn]
Bepouka, Ben [VerfasserIn]
Mbula, Marcel [VerfasserIn]
Kayembe, Jean-Marie [VerfasserIn]
Mvumbi, Georges [VerfasserIn]
Hayette, Marie-Pierre [VerfasserIn]

Links:

Volltext

Themen:

Case Reports
Clinical signs
Democratic Republic of Congo
Epidemiology
HIV
Neuromeningeal cryptococcosis

Anmerkungen:

Date Completed 11.03.2021

Date Revised 11.03.2021

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.11604/pamj.2020.37.302.20521

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM322120152