Not etched in bone : the role of osteoclast proton-sensing receptors

Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved..

The osteoclast proton-sensing receptors may play a role in osteoclastogenesis or bone resorption. The current study by Kreiger et al. found that in female mice, osteoclast-specific deletion of the gene for OGR1 resulted in increased bone mass, which demonstrates that in some situations this receptor is playing a role. However, there are some inconsistencies because the bone resorption was not reduced in their global knockout mice, and the effects are not seen in both genders or by other investigators. More work should be done to better define the role of OGR1 because acidosis is an important cause of bone loss.

Errataetall:

CommentOn: Kidney Int. 2021 Mar;99(3):609-619. - PMID 33159961

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:99

Enthalten in:

Kidney international - 99(2021), 3 vom: 12. März, Seite 542-545

Sprache:

Englisch

Beteiligte Personen:

Ott, Susan M [VerfasserIn]

Links:

Volltext

Themen:

Comment
Journal Article
Protons
Receptors, G-Protein-Coupled

Anmerkungen:

Date Completed 05.03.2021

Date Revised 05.03.2021

published: Print

CommentOn: Kidney Int. 2021 Mar;99(3):609-619. - PMID 33159961

Citation Status MEDLINE

doi:

10.1016/j.kint.2020.11.022

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321953185