Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissionsoup.com..
BACKGROUND: Cardiovascular disease (CVD) risk factors are transmitted from parents to children. We prospectively examined the association between parental cardiovascular health (CVH) and time to onset of CVD in the offspring.
METHODS AND RESULTS: The study consisted of a total of 5967 offspring-mother-father trios derived from the Framingham Heart Study. Cardiovascular health score was defined using the seven American Heart Association's CVH metrics attained at ideal levels: poor (0-2), intermediate (3-4), and ideal CVH (5-7). Multivariable-adjusted Cox proportional hazards regression models, Kaplan-Meier plots, and Irwin's restricted mean were used to examine the association and sex-specific differences between parental CVH and offspring's CVD-free survival. In a total of 71 974 person-years of follow-up among the offspring, 718 incident CVD events occurred. The overall CVD incidence rate was 10 per 1000 person-years [95% confidence interval (CI) 9.3-10.7]. Offspring of mothers with ideal CVH lived 9 more years free of CVD than offspring of mothers with poor CVH (P < 0.001). Maternal poor CVH was associated with twice as high hazard of early onset of CVD compared with maternal ideal CVH (adjusted Hazard Ratio 2.09, 95% CI 1.50-2.92). No statistically significant association was observed in the hazards of CVD-free survival by paternal CVH categories.
CONCLUSIONS: We found that offspring of parents with ideal CVH had a greater CVD-free survival. Maternal CVH was a more robust predictor of offspring's CVD-free survival than paternal CVH, underscoring the need for clinical and policy interventions that involve mothers to break the intergenerational cycle of CVD-related morbidity and mortality.
Errataetall: |
CommentIn: Eur J Prev Cardiol. 2022 May 6;29(6):880-882. - PMID 33624077 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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Enthalten in: |
European journal of preventive cardiology - 29(2022), 6 vom: 06. Mai, Seite 883-891 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Muchira, James M [VerfasserIn] |
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Links: |
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Themen: |
Cardiovascular disease |
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Anmerkungen: |
Date Completed 10.05.2022 Date Revised 14.06.2022 published: Print CommentIn: Eur J Prev Cardiol. 2022 May 6;29(6):880-882. - PMID 33624077 Citation Status MEDLINE |
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doi: |
10.1093/eurjpc/zwaa072 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM321823672 |
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500 | |a Citation Status MEDLINE | ||
520 | |a Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissionsoup.com. | ||
520 | |a BACKGROUND: Cardiovascular disease (CVD) risk factors are transmitted from parents to children. We prospectively examined the association between parental cardiovascular health (CVH) and time to onset of CVD in the offspring | ||
520 | |a METHODS AND RESULTS: The study consisted of a total of 5967 offspring-mother-father trios derived from the Framingham Heart Study. Cardiovascular health score was defined using the seven American Heart Association's CVH metrics attained at ideal levels: poor (0-2), intermediate (3-4), and ideal CVH (5-7). Multivariable-adjusted Cox proportional hazards regression models, Kaplan-Meier plots, and Irwin's restricted mean were used to examine the association and sex-specific differences between parental CVH and offspring's CVD-free survival. In a total of 71 974 person-years of follow-up among the offspring, 718 incident CVD events occurred. The overall CVD incidence rate was 10 per 1000 person-years [95% confidence interval (CI) 9.3-10.7]. Offspring of mothers with ideal CVH lived 9 more years free of CVD than offspring of mothers with poor CVH (P < 0.001). Maternal poor CVH was associated with twice as high hazard of early onset of CVD compared with maternal ideal CVH (adjusted Hazard Ratio 2.09, 95% CI 1.50-2.92). No statistically significant association was observed in the hazards of CVD-free survival by paternal CVH categories | ||
520 | |a CONCLUSIONS: We found that offspring of parents with ideal CVH had a greater CVD-free survival. Maternal CVH was a more robust predictor of offspring's CVD-free survival than paternal CVH, underscoring the need for clinical and policy interventions that involve mothers to break the intergenerational cycle of CVD-related morbidity and mortality | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Cardiovascular disease | |
650 | 4 | |a Ideal cardiovascular health | |
650 | 4 | |a Offspring | |
650 | 4 | |a Parents | |
650 | 4 | |a Survival | |
700 | 1 | |a Gona, Philimon N |e verfasserin |4 aut | |
700 | 1 | |a Mogos, Mulubrhan F |e verfasserin |4 aut | |
700 | 1 | |a Stuart-Shor, Eileen |e verfasserin |4 aut | |
700 | 1 | |a Leveille, Suzanne G |e verfasserin |4 aut | |
700 | 1 | |a Piano, Mariann R |e verfasserin |4 aut | |
700 | 1 | |a Hayman, Laura L |e verfasserin |4 aut | |
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