Hormone Replacement Therapy and Aging : A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling

Copyright © 2021 Renáta Szabó et al..

Advanced age is an independent risk factor for cardiovascular diseases, which might be further exacerbated by estrogen deficiency. Hormone replacement therapy (HRT) decreases cardiovascular risks and events in postmenopausal women; however, its effects are not fully elucidated in older individuals. Thus, the aim of our study is to examine the impact of HRT on oxidant/antioxidant homeostasis and cardiac remodeling. In our experiment, control (fertile) and aging (~20-month-old) female Wistar rats were used. Aging rats were further divided into estrogen- (E2, 0.1 mg/kg/day per os) or raloxifene- (RAL, 1.0 mg/kg/day per os) treated subgroups. After 2 weeks of treatment, cardiac heme oxygenase (HO) activity, total glutathione (GSH) content, matrix metalloproteinase-2 (MMP-2) activity, and the concentrations of collagen type I and tissue inhibitor of metalloproteinase (TIMP-2), as well as the infarct size, were determined. The aging process significantly decreased the antioxidant HO activity and GSH content, altered the MMP-2/TIMP-2 signaling, and resulted in an excessive collagen accumulation, which culminated in cardiovascular injury. However, 2 weeks of either E2 or RAL treatment enhanced the antioxidant defense mechanisms and attenuated cardiac remodeling related to aging. Our findings clearly show that 2-week-long HRT is a potential intervention to bias successful cardiovascular aging via reducing oxidative damage and cardiovascular dysfunction.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:2021

Enthalten in:

Oxidative medicine and cellular longevity - 2021(2021) vom: 23., Seite 8364297

Sprache:

Englisch

Beteiligte Personen:

Szabó, Renáta [VerfasserIn]
Hoffmann, Alexandra [VerfasserIn]
Börzsei, Denise [VerfasserIn]
Kupai, Krisztina [VerfasserIn]
Veszelka, Médea [VerfasserIn]
Berkó, Anikó Magyariné [VerfasserIn]
Pávó, Imre [VerfasserIn]
Gesztelyi, Rudolf [VerfasserIn]
Juhász, Béla [VerfasserIn]
Turcsán, Zsolt [VerfasserIn]
Pósa, Anikó [VerfasserIn]
Varga, Csaba [VerfasserIn]

Links:

Volltext

Themen:

4F86W47BR6
Collagen Type I
EC 1.14.14.18
EC 3.4.24.24
Estrogens
GAN16C9B8O
Glutathione
Heme Oxygenase (Decyclizing)
Journal Article
Matrix Metalloproteinase 2
Raloxifene Hydrochloride

Anmerkungen:

Date Completed 09.09.2021

Date Revised 26.02.2024

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.1155/2021/8364297

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321819632