Cerebral Metabolite Concentrations Are Associated With Cortical and Subcortical Volumes and Cognition in Older Adults
Copyright © 2021 Williamson, Lamb, Porges, Bottari, Woods, Datta, Langer and Cohen..
BACKGROUND: Cerebral metabolites are associated with different physiological processes in brain aging. Cortical and limbic structures play important roles in cognitive aging; however, the relationship between these structures and age remains unclear with respect to physiological underpinnings. Regional differences in metabolite levels may be related to different structural and cognitive changes in aging.
METHODS: Magnetic resonance imaging and spectroscopy were obtained from 117 cognitively healthy older adults. Limbic and other key structural volumes were measured. Concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) were measured in frontal and parietal regions. Neuropsychological testing was performed including measures of crystallized and fluid intelligence and memory.
RESULTS: NAA in the frontal voxel was associated with limbic and cortical volumes, whereas Cho in parietal cortex was negatively associated with hippocampal and other regional volumes. Hippocampal volume was associated with forgetting, independent of age. Further, parietal Cho and hippocampal volume contributed independent variance to age corrected discrepancy between fluid and crystallized abilities.
CONCLUSION: These findings suggest that physiological changes with age in the frontal and parietal cortices may be linked to structural changes in other connected brain regions. These changes are differentially associated with cognitive performance, suggesting potentially divergent mechanisms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in aging neuroscience - 12(2020) vom: 17., Seite 587104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Williamson, John B [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer’s disease |
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| Anmerkungen: |
Date Revised 20.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fnagi.2020.587104 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321718453 |
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| 245 | 1 | 0 | |a Cerebral Metabolite Concentrations Are Associated With Cortical and Subcortical Volumes and Cognition in Older Adults |
| 264 | 1 | |c 2020 | |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 Williamson, Lamb, Porges, Bottari, Woods, Datta, Langer and Cohen. | ||
| 520 | |a BACKGROUND: Cerebral metabolites are associated with different physiological processes in brain aging. Cortical and limbic structures play important roles in cognitive aging; however, the relationship between these structures and age remains unclear with respect to physiological underpinnings. Regional differences in metabolite levels may be related to different structural and cognitive changes in aging | ||
| 520 | |a METHODS: Magnetic resonance imaging and spectroscopy were obtained from 117 cognitively healthy older adults. Limbic and other key structural volumes were measured. Concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) were measured in frontal and parietal regions. Neuropsychological testing was performed including measures of crystallized and fluid intelligence and memory | ||
| 520 | |a RESULTS: NAA in the frontal voxel was associated with limbic and cortical volumes, whereas Cho in parietal cortex was negatively associated with hippocampal and other regional volumes. Hippocampal volume was associated with forgetting, independent of age. Further, parietal Cho and hippocampal volume contributed independent variance to age corrected discrepancy between fluid and crystallized abilities | ||
| 520 | |a CONCLUSION: These findings suggest that physiological changes with age in the frontal and parietal cortices may be linked to structural changes in other connected brain regions. These changes are differentially associated with cognitive performance, suggesting potentially divergent mechanisms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a MRS | |
| 650 | 4 | |a N-acetylaspartate | |
| 650 | 4 | |a brain volume | |
| 650 | 4 | |a choline | |
| 650 | 4 | |a cognitive | |
| 650 | 4 | |a healthy aging | |
| 700 | 1 | |a Lamb, Damon G |e verfasserin |4 aut | |
| 700 | 1 | |a Porges, Eric C |e verfasserin |4 aut | |
| 700 | 1 | |a Bottari, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Woods, Adam J |e verfasserin |4 aut | |
| 700 | 1 | |a Datta, Somnath |e verfasserin |4 aut | |
| 700 | 1 | |a Langer, Kailey |e verfasserin |4 aut | |
| 700 | 1 | |a Cohen, Ronald A |e verfasserin |4 aut | |
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