Advancement and properties of circular RNAs in prostate cancer : An emerging and compelling frontier for discovering

© The author(s)..

Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What's more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:17

Enthalten in:

International journal of biological sciences - 17(2021), 2 vom: 15., Seite 651-669

Sprache:

Englisch

Beteiligte Personen:

Zhou, Hong [VerfasserIn]
Zheng, Xu-Dong [VerfasserIn]
Lin, Chang-Ming [VerfasserIn]
Min, Jie [VerfasserIn]
Hu, Shuang [VerfasserIn]
Hu, Ying [VerfasserIn]
Li, Liang-Yun [VerfasserIn]
Chen, Jia-Si [VerfasserIn]
Liu, Yu-Min [VerfasserIn]
Li, Hao-Dong [VerfasserIn]
Meng, Xiao-Ming [VerfasserIn]
Li, Jun [VerfasserIn]
Yang, Ya-Ru [VerfasserIn]
Xu, Tao [VerfasserIn]

Links:

Volltext

Themen:

Biomarker
Biomarkers, Tumor
Circular RNA
Journal Article
MicroRNA
Prostate cancer (PC)
RNA, Circular
Research Support, Non-U.S. Gov't
Review
Tumorigenesis

Anmerkungen:

Date Completed 03.01.2022

Date Revised 03.01.2022

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.7150/ijbs.52266

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321717090