Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
eLife - 10(2021) vom: 18. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maximova, Olga A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.01.2022 Date Revised 19.09.2023 published: Electronic GEO: GSE122798 Citation Status MEDLINE |
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| doi: |
10.7554/eLife.62273 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321584430 |
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| 100 | 1 | |a Maximova, Olga A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 28.01.2022 | ||
| 500 | |a Date Revised 19.09.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a GEO: GSE122798 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a functional genomics | |
| 650 | 4 | |a immune system | |
| 650 | 4 | |a immunology | |
| 650 | 4 | |a infectious disease | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a microbiology | |
| 650 | 4 | |a neuronal system | |
| 650 | 4 | |a pleiotropic genes | |
| 650 | 4 | |a rhesus macaque | |
| 650 | 4 | |a synapses | |
| 650 | 4 | |a virus | |
| 700 | 1 | |a Sturdevant, Daniel E |e verfasserin |4 aut | |
| 700 | 1 | |a Kash, John C |e verfasserin |4 aut | |
| 700 | 1 | |a Kanakabandi, Kishore |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Yongli |e verfasserin |4 aut | |
| 700 | 1 | |a Minai, Mahnaz |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Ian N |e verfasserin |4 aut | |
| 700 | 1 | |a Taubenberger, Jeff |e verfasserin |4 aut | |
| 700 | 1 | |a Martens, Craig |e verfasserin |4 aut | |
| 700 | 1 | |a Cohen, Jeffrey I |e verfasserin |4 aut | |
| 700 | 1 | |a Pletnev, Alexander G |e verfasserin |4 aut | |
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