Maturation Block in Childhood Cancer

©2021 American Association for Cancer Research..

The key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers arising within aging cell hierarchies, as a consequence of accumulated damage and mutagenesis, in contrast to childhood tumors that are born in aberrantly developing tissues. A distinct biological property of childhood tumor cells-a block of developmental maturation-may hold the key to advancing the treatment of childhood cancer beyond cytotoxic strategies.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

Cancer discovery - 11(2021), 3 vom: 16. März, Seite 542-544

Sprache:

Englisch

Beteiligte Personen:

Behjati, Sam [VerfasserIn]
Gilbertson, Richard J [VerfasserIn]
Pfister, Stefan M [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers, Tumor
Letter
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 19.01.2022

Date Revised 10.02.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1158/2159-8290.CD-20-0926

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321488245