Sensor-Based Frailty Assessment in Survivors of Childhood Cancer : A Pilot Study

BACKGROUND: Survivors of childhood cancer (CCS) are at risk for early aging and frailty. Frailty in CCS has been assessed with established clinical criteria, a time-intensive approach requiring specialized training. There is an unmet need for cost-effective, rapid methods for assessing frailty in at-risk adolescent and young adult (AYA) CCS, which are scalable to large populations.

OBJECTIVES: To validate a sensor-based frailty assessment tool in AYA CCS, compare frailty status between CCS and controls, and assess the correlation between frailty and number of CCS comorbidities.

DESIGN, SETTING, AND PARTICIPANTS: Mean frailty index (MFI) was assessed by a frailty wrist sensor in 32 AYA CCS who were ≥1 year off therapy and in remission. Results were compared with 32 AYA controls without cancer or chronic disease.

MEASUREMENTS: Frailty assessments with and without a simultaneous cognitive task were performed to obtain MFI. Results were compared between cases and controls using a Student t test, and the number of pre-frail/frail subjects by Chi Square test. The contribution of radiation therapy (RT) exposure to MFI was assessed in a sub-analysis, and the correlation between the number of comorbidities and MFI was measured using the Pearson method.

RESULTS: MFI was strongly correlated with gait speed in AYA CCS. CCS were more likely to be pre-frail than controls without cancer history (p=0.032), and CCS treated with RT were more likely to be pre-frail than CCS not treated with RT (p<0.001). The number of comorbidities was strongly correlated with MFI (ρ=0.65), with a 0.028 increase in MFI for each added condition (p<0.001).

CONCLUSIONS: Results from this study support higher risk for frailty among CCS, especially those with multiple comorbidities or who were treated with RT. A wrist-worn sensor-based method is feasible for application in AYA CCS, and provides an opportunity for cost-effective, rapid screening of at-risk AYA CCS who may benefit from early interventions.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

The Journal of frailty & aging - 10(2021), 2 vom: 11., Seite 176-181

Sprache:

Englisch

Beteiligte Personen:

Krnavek, N J [VerfasserIn]
Ajasin, S [VerfasserIn]
Arreola, E C [VerfasserIn]
Zahiri, M [VerfasserIn]
Noun, M [VerfasserIn]
Lupo, P J [VerfasserIn]
Najafi, B [VerfasserIn]
Gramatges, M M [VerfasserIn]

Links:

Volltext

Themen:

Frailty
Journal Article
Slowness
Survivorship
Weakness

Anmerkungen:

Date Completed 17.02.2021

Date Revised 17.02.2021

published: Print

Citation Status MEDLINE

doi:

10.14283/jfa.2020.71

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321356160