D-dimer daily continuous tendency predicts the short-term prognosis for COVID-19 independently : A retrospective study from Northeast China

BACKGROUND AND OBJECTIVE: To study whether D-dimer daily continuous tendency could predict the short-term prognosis of COVID-19.

PATIENTS AND METHODES: According to the short-term prognosis, 81 COVID-19 patients were divided into two groups, one of worse prognosis (Group W) and the other of better prognosis (Group B). The slope of D-dimer linear regression during hospitalization (SLOPE) was calculated as an indicator of D-dimer daily continuous tendency. The SLOPE difference between Group W and Group B was compared. The difference between the discharge results and the 3-month follow-up results was also compared. COX regression analysis was used to analyze the relationship between SLOPE and short-term prognosis of COVID-19.

RESULTS: There were 16 patients in Group W and 65 patients in Group B. Group W had more critical proportion (p < 0.0001), indicating that the symptoms of its patients were more severe during hospitalization. ARDS, the most visible cause of worse prognosis, accounted for up to 68.75%, and many symptoms merged and resulted in worse prognosis. The D-dimer levels of Group W not only were significantly higher (p < 0.0001), but also showed an increasing trend. In addition, the D-dimer levels at discharge were significantly higher than those at follow-up (p = 0.0261), and the mean difference was as high as 0.7474. SLOPE significantly correlated with the short-term prognosis of COVID-19 independently (RR: 1.687, 95% CI: 1.345-2.116, P < 0.0001). The worst prognosis occurred most likely during the first month after COVID-19 diagnosis.

CONCLUSION: Our study found that D-dimer daily continuous tendency independently correlates with worse prognosis and can be used as an independent predictor of the short-term prognosis for COVID-19.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:79

Enthalten in:

Clinical hemorheology and microcirculation - 79(2021), 2 vom: 06., Seite 269-277

Sprache:

Englisch

Beteiligte Personen:

Xing, Yinting [VerfasserIn]
Yang, Wei [VerfasserIn]
Jin, Yingyu [VerfasserIn]
Wang, Chao [VerfasserIn]
Guan, Xiuru [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers
Coronavirus disease 2019 (COVID-19)
D-dimer
Fibrin Fibrinogen Degradation Products
Fibrin fragment D
Journal Article
Nomogram
Prognosis
SARS-CoV-2

Anmerkungen:

Date Completed 25.11.2021

Date Revised 25.11.2021

published: Print

Citation Status MEDLINE

doi:

10.3233/CH-201071

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM321154088