Association of Genetic Variants of the Interleukin-17F rs763780 and its Circulating Level in Psoriasis Patients in Egypt
Copyright© by the Egyptian Association of Immunologists..
Psoriasis is a chronic autoimmune disease affecting the skin and joints, IL- 17 family has been shown to be the major effector cytokine in its pathogenesis. This study aimed to investigate genetic polymorphism of IL-17F (rs763780) and evaluate the impact of this polymorphism on circulating levels of IL-17F as a potential risk locus for psoriasis. 60 patients suffering from chronic plaque psoriasis and 60 healthy controls were genotyped for the IL-17F (rs763780) using an Amplification Refractory Mutation System -PCR (ARMS-PCR) method. Measurement of serum IL-17F was also done by ELISA. There was a significant difference in frequency between TT and TC genotypes (OR= 2.74, 95%CI=1.04 -7.4, P=0.04) and TT and CC genotypes (OR=10.9, 95%CI=1.3-91.3, P=0.007). Moreover, the TC and CC genotypes were associated with increased risk of psoriasis in comparison with the TT genotype. (OR= 3.8, 95% CI: 1.5- 9.4, P= 0.003). The mutant allele, C, was significantly associated with an increased risk of psoriasis compared to that with the wild T allele, T (OR= 4.1, 95% CI: 1.9- 9.1, P= 0.0002). Serum level of IL-17F was higher among psoriasis patients (25.7±3.8pg/ml) than healthy controls ((15.1±2.1pg/ mL). In conclusion, IL17F polymorphism (rs763780) is associated with increased risk of psoriasis and may influence the level of production of IL-17F with subsequent effects on the pathogenesis of psoriasis.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
The Egyptian journal of immunology - 27(2020), 2 vom: 20. Juni, Seite 39-46 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fouad, Nehad A [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 17.02.2021 Date Revised 17.02.2021 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321095146 |
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| 245 | 1 | 0 | |a Association of Genetic Variants of the Interleukin-17F rs763780 and its Circulating Level in Psoriasis Patients in Egypt |
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| 520 | |a Copyright© by the Egyptian Association of Immunologists. | ||
| 520 | |a Psoriasis is a chronic autoimmune disease affecting the skin and joints, IL- 17 family has been shown to be the major effector cytokine in its pathogenesis. This study aimed to investigate genetic polymorphism of IL-17F (rs763780) and evaluate the impact of this polymorphism on circulating levels of IL-17F as a potential risk locus for psoriasis. 60 patients suffering from chronic plaque psoriasis and 60 healthy controls were genotyped for the IL-17F (rs763780) using an Amplification Refractory Mutation System -PCR (ARMS-PCR) method. Measurement of serum IL-17F was also done by ELISA. There was a significant difference in frequency between TT and TC genotypes (OR= 2.74, 95%CI=1.04 -7.4, P=0.04) and TT and CC genotypes (OR=10.9, 95%CI=1.3-91.3, P=0.007). Moreover, the TC and CC genotypes were associated with increased risk of psoriasis in comparison with the TT genotype. (OR= 3.8, 95% CI: 1.5- 9.4, P= 0.003). The mutant allele, C, was significantly associated with an increased risk of psoriasis compared to that with the wild T allele, T (OR= 4.1, 95% CI: 1.9- 9.1, P= 0.0002). Serum level of IL-17F was higher among psoriasis patients (25.7±3.8pg/ml) than healthy controls ((15.1±2.1pg/ mL). In conclusion, IL17F polymorphism (rs763780) is associated with increased risk of psoriasis and may influence the level of production of IL-17F with subsequent effects on the pathogenesis of psoriasis | ||
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