MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer

Brian metastasis, which is diagnosed in 30% of triple-negative breast cancer (TNBC) patients with metastasis, causes poor survival outcomes. Growing evidence has characterized miRNAs involving in breast cancer brain metastasis; however, currently, there is a lack of prognostic plasma-based indicator for brain metastasis. In this study, high level of miR-211 can act as brain metastatic prognostic marker in vivo. High miR-211 drives early and specific brain colonization through enhancing trans-blood-brain barrier (BBB) migration, BBB adherence, and stemness properties of tumor cells and causes poor survival in vivo. SOX11 and NGN2 are the downstream targets of miR-211 and negatively regulate miR-211-mediated TNBC brain metastasis in vitro and in vivo. Most importantly, high miR-211 is correlated with poor survival and brain metastasis in TNBC patients. Our findings suggest that miR-211 may be used as an indicator for TNBC brain metastasis.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

Oncogene - 40(2021), 9 vom: 03. März, Seite 1737-1751

Sprache:

Englisch

Beteiligte Personen:

Pan, Jhih-Kai [VerfasserIn]
Lin, Cheng-Han [VerfasserIn]
Kuo, Yao-Lung [VerfasserIn]
Ger, Luo-Ping [VerfasserIn]
Cheng, Hui-Chuan [VerfasserIn]
Yao, Yun-Chin [VerfasserIn]
Hsiao, Michael [VerfasserIn]
Lu, Pei-Jung [VerfasserIn]

Links:

Volltext

Themen:

Basic Helix-Loop-Helix Transcription Factors
Journal Article
MIRN211 microRNA, human
MicroRNAs
NEUROG2 protein, human
Nerve Tissue Proteins
SOX11 protein, human
SOXC Transcription Factors

Anmerkungen:

Date Completed 29.07.2021

Date Revised 31.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1038/s41388-021-01654-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM320973298