Mystery Checkpoint Revealed : KIR3DL3 Finally Found a Ligand in HHLA2
©2021 American Association for Cancer Research..
Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2+ tumor cells from immune attack.See article by Bhatt et al., p. 156.
| Errataetall: |
CommentOn: Cancer Immunol Res. 2021 Feb;9(2):156-169. - PMID 33229411 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Cancer immunology research - 9(2021), 2 vom: 31. Feb., Seite 128 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Campbell, Kerry S [VerfasserIn] |
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Date Completed 29.06.2021 Date Revised 29.06.2021 published: Print CommentOn: Cancer Immunol Res. 2021 Feb;9(2):156-169. - PMID 33229411 Citation Status MEDLINE |
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| doi: |
10.1158/2326-6066.CIR-20-0996 |
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NLM320970191 |
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| 520 | |a Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2+ tumor cells from immune attack.See article by Bhatt et al., p. 156 | ||
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