Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines

The first Ni(OTf)2-catalyzed hydroamination of ynamides 2 was developed by reacting with secondary amines (1 and 4). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:86

Enthalten in:

The Journal of organic chemistry - 86(2021), 4 vom: 19. Feb., Seite 3433-3443

Sprache:

Englisch

Beteiligte Personen:

Nie, Xiao-Di [VerfasserIn]
Han, Xiao-Li [VerfasserIn]
Sun, Jian-Ting [VerfasserIn]
Si, Chang-Mei [VerfasserIn]
Wei, Bang-Guo [VerfasserIn]
Lin, Guo-Qiang [VerfasserIn]

Links:

Volltext

Themen:

7OV03QG267
Amines
Journal Article
Nickel
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 02.07.2021

Date Revised 02.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1021/acs.joc.0c02807

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM320944522