Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines
The first Ni(OTf)2-catalyzed hydroamination of ynamides 2 was developed by reacting with secondary amines (1 and 4). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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Enthalten in: |
The Journal of organic chemistry - 86(2021), 4 vom: 19. Feb., Seite 3433-3443 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Nie, Xiao-Di [VerfasserIn] |
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Links: |
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Themen: |
7OV03QG267 |
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Anmerkungen: |
Date Completed 02.07.2021 Date Revised 02.07.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1021/acs.joc.0c02807 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM320944522 |
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520 | |a The first Ni(OTf)2-catalyzed hydroamination of ynamides 2 was developed by reacting with secondary amines (1 and 4). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities | ||
650 | 4 | |a Journal Article | |
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700 | 1 | |a Wei, Bang-Guo |e verfasserin |4 aut | |
700 | 1 | |a Lin, Guo-Qiang |e verfasserin |4 aut | |
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