Efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis by rebalancing skin microecology
© 2021 Wiley Periodicals LLC..
This study investigated the mechanism and efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis (AO). A total of 32 AO patients were enrolled in this study. In the initial pilot study, 20 patients were double-blindly, randomly divided into acidified aliphatic ester or aliphatic ester treatment groups, followed by efficacy evaluation after 4 weeks. Then, all patients (n = 32) were treated with topical acidified aliphatic ester for 16 weeks. Efficacy was evaluated at every 4 weeks, and at 3- and 6-month follow-ups. Changes of pH values and microecology at targeting sites were analyzed. In the first cohort (n = 20) of pilot study, acidified aliphatic ester showed significantly higher curative rate (60% vs 10%, P < .05) and effective rate (90% vs 30%; P < .05) than aliphatic ester. For the next 16 weeks, 25 of 32 cases completed treatment. Curative rate showed gradual and significant increases from 64% to 96% during the treatment courses (P = .001); it slightly but insignificantly decreased at 3- and 6- month follow-ups. Abundance of Corynebacterium and Anaerobic bacteria decreased while Staphylococcus increased after treatments. Axillary pH values negatively correlated with Staphylococcus abundance (r = -.40, P = .01) and positively with Corynebacterium abundance (r = .64, P = .01). We concluded that topical acidified aliphatic ester could effectively alleviate conditions of AO patients by reducing value of axillary pH and rebalancing axillary microecology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Dermatologic therapy - 34(2021), 2 vom: 08. März, Seite e14844 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zeng, Jinrong [VerfasserIn] |
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| Links: |
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| Themen: |
Acidified aliphatic ester |
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| Anmerkungen: |
Date Completed 25.05.2021 Date Revised 25.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/dth.14844 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320890686 |
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| 520 | |a This study investigated the mechanism and efficacy of topical acidified aliphatic ester for treatment of axillary osmidrosis (AO). A total of 32 AO patients were enrolled in this study. In the initial pilot study, 20 patients were double-blindly, randomly divided into acidified aliphatic ester or aliphatic ester treatment groups, followed by efficacy evaluation after 4 weeks. Then, all patients (n = 32) were treated with topical acidified aliphatic ester for 16 weeks. Efficacy was evaluated at every 4 weeks, and at 3- and 6-month follow-ups. Changes of pH values and microecology at targeting sites were analyzed. In the first cohort (n = 20) of pilot study, acidified aliphatic ester showed significantly higher curative rate (60% vs 10%, P < .05) and effective rate (90% vs 30%; P < .05) than aliphatic ester. For the next 16 weeks, 25 of 32 cases completed treatment. Curative rate showed gradual and significant increases from 64% to 96% during the treatment courses (P = .001); it slightly but insignificantly decreased at 3- and 6- month follow-ups. Abundance of Corynebacterium and Anaerobic bacteria decreased while Staphylococcus increased after treatments. Axillary pH values negatively correlated with Staphylococcus abundance (r = -.40, P = .01) and positively with Corynebacterium abundance (r = .64, P = .01). We concluded that topical acidified aliphatic ester could effectively alleviate conditions of AO patients by reducing value of axillary pH and rebalancing axillary microecology | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a acidified aliphatic ester | |
| 650 | 4 | |a axillary osmidrosis | |
| 650 | 4 | |a microbiology | |
| 650 | 4 | |a skin pH | |
| 650 | 4 | |a treatment | |
| 650 | 7 | |a Esters |2 NLM | |
| 700 | 1 | |a Du, Hongjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuezhong |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Xiaoliang |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Lihua |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Yaping |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Wenbin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Shu |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Jianyun |e verfasserin |4 aut | |
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