Nonclassic Congenital Adrenal Hyperplasia : What Do Endocrinologists Need to Know?
Copyright © 2020 Elsevier Inc. All rights reserved..
Congenital adrenal hyperplasia encompasses a group of autosomal recessive defects in cortisol biosynthesis, and 21-hydroxylase deficiency accounts for 95% of such cases. Non-classic 21-hydroxylase deficiency is due to partial enzymatic defects, which present with normal cortisol synthesis, but excessive production of adrenal androgens, including 11-oxygenated androgens. Non-classic 21-hydroxylase deficiency is relatively common, and its phenotype resembles closely that of polycystic ovary syndrome. This review focuses primarily on non-classic 21-hydroxylase deficiency, its clinical features, diagnosis, and management.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
|---|---|
| Enthalten in: |
Endocrinology and metabolism clinics of North America - 50(2021), 1 vom: 01. März, Seite 151-165 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jha, Smita [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
21-Hydroxylase deficiency |
|---|
| Anmerkungen: |
Date Completed 25.10.2021 Date Revised 10.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ecl.2020.10.008 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM320794482 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM320794482 | ||
| 003 | DE-627 | ||
| 005 | 20231225174355.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ecl.2020.10.008 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1069.xml |
| 035 | |a (DE-627)NLM320794482 | ||
| 035 | |a (NLM)33518183 | ||
| 035 | |a (PII)S0889-8529(20)30086-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jha, Smita |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nonclassic Congenital Adrenal Hyperplasia |b What Do Endocrinologists Need to Know? |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.10.2021 | ||
| 500 | |a Date Revised 10.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a Congenital adrenal hyperplasia encompasses a group of autosomal recessive defects in cortisol biosynthesis, and 21-hydroxylase deficiency accounts for 95% of such cases. Non-classic 21-hydroxylase deficiency is due to partial enzymatic defects, which present with normal cortisol synthesis, but excessive production of adrenal androgens, including 11-oxygenated androgens. Non-classic 21-hydroxylase deficiency is relatively common, and its phenotype resembles closely that of polycystic ovary syndrome. This review focuses primarily on non-classic 21-hydroxylase deficiency, its clinical features, diagnosis, and management | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a 21-Hydroxylase deficiency | |
| 650 | 4 | |a Adrenal | |
| 650 | 4 | |a Adrenal cortex | |
| 650 | 4 | |a Androgens | |
| 650 | 4 | |a Congenital adrenal hyperplasia | |
| 650 | 7 | |a Androgens |2 NLM | |
| 700 | 1 | |a Turcu, Adina F |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Endocrinology and metabolism clinics of North America |d 1996 |g 50(2021), 1 vom: 01. März, Seite 151-165 |w (DE-627)NLM013004832 |x 1558-4410 |7 nnns |
| 773 | 1 | 8 | |g volume:50 |g year:2021 |g number:1 |g day:01 |g month:03 |g pages:151-165 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ecl.2020.10.008 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 50 |j 2021 |e 1 |b 01 |c 03 |h 151-165 | ||