Incremental value of left ventricular shape parameters measured by gated SPECT MPI in predicting the super-response to CRT

© 2021. American Society of Nuclear Cardiology..

BACKGROUND: The purpose of this study was to evaluate the predictive value of left ventricular (LV) shape parameters measured by gated SPECT myocardial perfusion imaging (MPI) in super-responders enrolled in the VISION-CRT trial.

METHODS: One hundred and ninety-nine patients who met standard criteria for CRT from multiple centers were enrolled in this study. End-systolic eccentricity (ESE) and end-diastolic eccentricity (EDE) were measures of LV shape. Super-responders were the patients who had a relative increase in left ventricular ejection fraction (LVEF) ≥ 15%.

RESULTS: Complete data were obtained in 165 patients, and 43.6% of them were classified as super-responders. ESE was an independent predictor of CRT super-responders in univariate (OR 12.59, 95% CI 1.56-101.35, P = .017) and multivariate analysis (OR 35.71, 95% CI 1.66-766.03, P = .006). ESE had an incremental value over significant clinical and SPECT imaging variables, including angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker, coronary artery disease, myocardial infarction, LVEF, end-diastolic volume index, and scar burden (AUC 0.82 vs. 0.80, sensitivity 0.68 vs. 0.65, specificity 0.82 vs. 0.78).

CONCLUSIONS: LV shape parameters derived from gated SPECT MPI have the promise to improve the prediction of the super-response to CRT. Moreover, ESE provides incremental value over existing clinical and nuclear imaging variables.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:29

Enthalten in:

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 29(2022), 4 vom: 07. Aug., Seite 1537-1546

Sprache:

Englisch

Beteiligte Personen:

He, Zhuo [VerfasserIn]
de Amorim Fernandes, Fernando [VerfasserIn]
do Nascimento, Erivelton Alessandro [VerfasserIn]
Garcia, Ernest V [VerfasserIn]
Mesquita, Claudio T [VerfasserIn]
Zhou, Weihua [VerfasserIn]

Links:

Volltext

Themen:

CRT
Heart failure
Journal Article
SPECT
Shape index
Super-responder

Anmerkungen:

Date Completed 04.08.2022

Date Revised 23.03.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s12350-020-02469-7

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM32068105X