Incremental value of left ventricular shape parameters measured by gated SPECT MPI in predicting the super-response to CRT
© 2021. American Society of Nuclear Cardiology..
BACKGROUND: The purpose of this study was to evaluate the predictive value of left ventricular (LV) shape parameters measured by gated SPECT myocardial perfusion imaging (MPI) in super-responders enrolled in the VISION-CRT trial.
METHODS: One hundred and ninety-nine patients who met standard criteria for CRT from multiple centers were enrolled in this study. End-systolic eccentricity (ESE) and end-diastolic eccentricity (EDE) were measures of LV shape. Super-responders were the patients who had a relative increase in left ventricular ejection fraction (LVEF) ≥ 15%.
RESULTS: Complete data were obtained in 165 patients, and 43.6% of them were classified as super-responders. ESE was an independent predictor of CRT super-responders in univariate (OR 12.59, 95% CI 1.56-101.35, P = .017) and multivariate analysis (OR 35.71, 95% CI 1.66-766.03, P = .006). ESE had an incremental value over significant clinical and SPECT imaging variables, including angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker, coronary artery disease, myocardial infarction, LVEF, end-diastolic volume index, and scar burden (AUC 0.82 vs. 0.80, sensitivity 0.68 vs. 0.65, specificity 0.82 vs. 0.78).
CONCLUSIONS: LV shape parameters derived from gated SPECT MPI have the promise to improve the prediction of the super-response to CRT. Moreover, ESE provides incremental value over existing clinical and nuclear imaging variables.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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Enthalten in: |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 29(2022), 4 vom: 07. Aug., Seite 1537-1546 |
Sprache: |
Englisch |
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Beteiligte Personen: |
He, Zhuo [VerfasserIn] |
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Links: |
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Themen: |
CRT |
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Anmerkungen: |
Date Completed 04.08.2022 Date Revised 23.03.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s12350-020-02469-7 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM32068105X |
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520 | |a © 2021. American Society of Nuclear Cardiology. | ||
520 | |a BACKGROUND: The purpose of this study was to evaluate the predictive value of left ventricular (LV) shape parameters measured by gated SPECT myocardial perfusion imaging (MPI) in super-responders enrolled in the VISION-CRT trial | ||
520 | |a METHODS: One hundred and ninety-nine patients who met standard criteria for CRT from multiple centers were enrolled in this study. End-systolic eccentricity (ESE) and end-diastolic eccentricity (EDE) were measures of LV shape. Super-responders were the patients who had a relative increase in left ventricular ejection fraction (LVEF) ≥ 15% | ||
520 | |a RESULTS: Complete data were obtained in 165 patients, and 43.6% of them were classified as super-responders. ESE was an independent predictor of CRT super-responders in univariate (OR 12.59, 95% CI 1.56-101.35, P = .017) and multivariate analysis (OR 35.71, 95% CI 1.66-766.03, P = .006). ESE had an incremental value over significant clinical and SPECT imaging variables, including angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker, coronary artery disease, myocardial infarction, LVEF, end-diastolic volume index, and scar burden (AUC 0.82 vs. 0.80, sensitivity 0.68 vs. 0.65, specificity 0.82 vs. 0.78) | ||
520 | |a CONCLUSIONS: LV shape parameters derived from gated SPECT MPI have the promise to improve the prediction of the super-response to CRT. Moreover, ESE provides incremental value over existing clinical and nuclear imaging variables | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a CRT | |
650 | 4 | |a Heart failure | |
650 | 4 | |a SPECT | |
650 | 4 | |a Shape index | |
650 | 4 | |a Super-responder | |
700 | 1 | |a de Amorim Fernandes, Fernando |e verfasserin |4 aut | |
700 | 1 | |a do Nascimento, Erivelton Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Garcia, Ernest V |e verfasserin |4 aut | |
700 | 1 | |a Mesquita, Claudio T |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Weihua |e verfasserin |4 aut | |
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