Improvement in Near Vision Following Silodosin Treatment in Patients With Lower Urinary Tract Symptoms
PURPOSE: The objective of this study was to investigate the change in near visual function after the administration of oral silodosin to patients with lower urinary tract symptoms (LUTS).
METHODS: This prospective study included treatment-naive patients who were scheduled to start treatment with silodosin for LUTS. A comprehensive ophthalmological evaluation including the near vision and the automated pupillometry was performed at baseline and after 3 months of silodosin treatment. For subjective assessment of near visual ability and satisfaction, a Near Activity Visual Questionnaire-10 (NAVQ-10) was also used at the same time (higher scores indicating worse quality).
RESULTS: Of 23 patients enrolled in this study, 15 continued with silodosin (8 mg once daily) treatment for 3 months and completed a follow-up evaluation. The mean age of participants was 60.4±8.4 years. Distant visual acuity and spherical error were unchanged after silodosin treatment. However, near vision acuity (logMAR) was improved after treatment (right, 0.47±0.36 vs. 0.38±0.39, P=0.018; left, 0.41±0.37 vs. 0.31±0.34, P=0.068; both, 0.27±0.26 vs. 0.21±0.27, P=0.043). Pupil size under room light decreased significantly in both eyes (right, 3.77±0.60 vs. 3.16±0.58, P=0.001; left, 3.72±0.80 vs. 3.21±0.75, P=0.002). The Rasch scale at NAVQ-10 improved from 54.7±9.9 to 48.5±11.2 (P=0.004).
CONCLUSION: This preliminary study demonstrated that highly selective alpha-1A adrenergic receptor antagonists such as silodosin improve near visual acuity and quality in patients with LUTS/benign prostatic hyperplasia. Decrease in pupil size caused by inhibition of adrenergic alpha 1 mediated contraction of iris dilator muscle is a possible mechanism underlying improved near vision.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
International neurourology journal - 25(2021), 2 vom: 25. Juni, Seite 164-171 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shin, Hyun Jin [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 17.07.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5213/inj.2040274.137 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320658694 |
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| 100 | 1 | |a Shin, Hyun Jin |e verfasserin |4 aut | |
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| 500 | |a Date Revised 17.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a PURPOSE: The objective of this study was to investigate the change in near visual function after the administration of oral silodosin to patients with lower urinary tract symptoms (LUTS) | ||
| 520 | |a METHODS: This prospective study included treatment-naive patients who were scheduled to start treatment with silodosin for LUTS. A comprehensive ophthalmological evaluation including the near vision and the automated pupillometry was performed at baseline and after 3 months of silodosin treatment. For subjective assessment of near visual ability and satisfaction, a Near Activity Visual Questionnaire-10 (NAVQ-10) was also used at the same time (higher scores indicating worse quality) | ||
| 520 | |a RESULTS: Of 23 patients enrolled in this study, 15 continued with silodosin (8 mg once daily) treatment for 3 months and completed a follow-up evaluation. The mean age of participants was 60.4±8.4 years. Distant visual acuity and spherical error were unchanged after silodosin treatment. However, near vision acuity (logMAR) was improved after treatment (right, 0.47±0.36 vs. 0.38±0.39, P=0.018; left, 0.41±0.37 vs. 0.31±0.34, P=0.068; both, 0.27±0.26 vs. 0.21±0.27, P=0.043). Pupil size under room light decreased significantly in both eyes (right, 3.77±0.60 vs. 3.16±0.58, P=0.001; left, 3.72±0.80 vs. 3.21±0.75, P=0.002). The Rasch scale at NAVQ-10 improved from 54.7±9.9 to 48.5±11.2 (P=0.004) | ||
| 520 | |a CONCLUSION: This preliminary study demonstrated that highly selective alpha-1A adrenergic receptor antagonists such as silodosin improve near visual acuity and quality in patients with LUTS/benign prostatic hyperplasia. Decrease in pupil size caused by inhibition of adrenergic alpha 1 mediated contraction of iris dilator muscle is a possible mechanism underlying improved near vision | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Myopia | |
| 650 | 4 | |a Presbyopia | |
| 650 | 4 | |a Pupil | |
| 650 | 4 | |a Receptors, adrenergic, alpha-1 | |
| 650 | 4 | |a Silodosin | |
| 700 | 1 | |a Choi, Woo Suk |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Shin-Hyo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Andrew G |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Aram |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Hyoung Keun |e verfasserin |4 aut | |
| 700 | 1 | |a Paick, Sung Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyeong Gon |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:25 |g year:2021 |g number:2 |g day:25 |g month:06 |g pages:164-171 |
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