Embryotoxicity characterization of the flame retardant tris(1-chloro-2-propyl)phosphate (TCPP) in the invertebrate chordate Ciona intestinalis
© 2021 Wiley Periodicals LLC..
Tris(1-chloro-2-propyl)phosphate (TCPP) is the most common chlorinated organophosphorus flame retardant in seawater. Due to its chemical features and abundance, TCPP has been classified as a high hazard, and restrictions of use have been set in multiple countries. Despite TCPP being highly present in the marine environment, only a few studies have explored the TCPP impact on the development of marine invertebrates. Ascidians are important invertebrate members of benthic marine communities and reliable model systems for ecotoxicological research. The aim of this study was to assess the adverse effects of TCPP exposure on the embryogenesis of the ascidian Ciona intestinalis. Our results showed that this pollutant affected both muscles and nervous system development. Malformations appeared similar to those reported in other animal models for other flame retardants, suggesting that these molecules could share a common mechanism of action and induce a mixture effect when simultaneously present in the aquatic environment even at sub-teratogenic concentrations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:335 |
|---|---|
| Enthalten in: |
Journal of experimental zoology. Part A, Ecological and integrative physiology - 335(2021), 3 vom: 26. März, Seite 339-347 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mercurio, Silvia [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 21.07.2021 Date Revised 21.07.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/jez.2446 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM320651010 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM320651010 | ||
| 003 | DE-627 | ||
| 005 | 20231225174032.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jez.2446 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1068.xml |
| 035 | |a (DE-627)NLM320651010 | ||
| 035 | |a (NLM)33503327 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mercurio, Silvia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Embryotoxicity characterization of the flame retardant tris(1-chloro-2-propyl)phosphate (TCPP) in the invertebrate chordate Ciona intestinalis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.07.2021 | ||
| 500 | |a Date Revised 21.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 Wiley Periodicals LLC. | ||
| 520 | |a Tris(1-chloro-2-propyl)phosphate (TCPP) is the most common chlorinated organophosphorus flame retardant in seawater. Due to its chemical features and abundance, TCPP has been classified as a high hazard, and restrictions of use have been set in multiple countries. Despite TCPP being highly present in the marine environment, only a few studies have explored the TCPP impact on the development of marine invertebrates. Ascidians are important invertebrate members of benthic marine communities and reliable model systems for ecotoxicological research. The aim of this study was to assess the adverse effects of TCPP exposure on the embryogenesis of the ascidian Ciona intestinalis. Our results showed that this pollutant affected both muscles and nervous system development. Malformations appeared similar to those reported in other animal models for other flame retardants, suggesting that these molecules could share a common mechanism of action and induce a mixture effect when simultaneously present in the aquatic environment even at sub-teratogenic concentrations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a chlorinated organophosphorus flame retardant | |
| 650 | 4 | |a marine invertebrate | |
| 650 | 4 | |a muscle | |
| 650 | 4 | |a myogenesis | |
| 650 | 4 | |a nervous system | |
| 650 | 4 | |a neural development | |
| 650 | 7 | |a Flame Retardants |2 NLM | |
| 650 | 7 | |a Organophosphorus Compounds |2 NLM | |
| 650 | 7 | |a tri-(2-chloroisopropyl)phosphate |2 NLM | |
| 650 | 7 | |a 13674-84-5 |2 NLM | |
| 700 | 1 | |a Messinetti, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Manenti, Raoul |e verfasserin |4 aut | |
| 700 | 1 | |a Ficetola, Gentile Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Pennati, Roberta |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of experimental zoology. Part A, Ecological and integrative physiology |d 2017 |g 335(2021), 3 vom: 26. März, Seite 339-347 |w (DE-627)NLM269124683 |x 2471-5646 |7 nnns |
| 773 | 1 | 8 | |g volume:335 |g year:2021 |g number:3 |g day:26 |g month:03 |g pages:339-347 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/jez.2446 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 335 |j 2021 |e 3 |b 26 |c 03 |h 339-347 | ||