Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport : Binding Outside the Box
Na+/H+ exchange factor-1 (NHERF1), a multidomain PDZ scaffolding phosphoprotein, is required for the type II sodium-dependent phosphate cotransporter (NPT2A)-mediated renal phosphate absorption. Both PDZ1 and PDZ2 domains are involved in NPT2A-dependent phosphate uptake. Though harboring identical core-binding motifs, PDZ1 and PDZ2 play entirely different roles in hormone-regulated phosphate transport. PDZ1 is required for the interaction with the C-terminal PDZ-binding sequence of NPT2A (-TRL). Remarkably, phosphocycling at Ser290 distant from PDZ1, the penultimate step for both parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) regulation, controls the association between NHERF1 and NPT2A. PDZ2 interacts with the C-terminal PDZ-recognition motif (-TRL) of G Protein-coupled Receptor Kinase 6A (GRK6A), and that promotes phosphorylation of Ser290. The compelling biological puzzle is how PDZ1 and PDZ2 with identical GYGF core-binding motifs specifically recognize distinct binding partners. Binding determinants distinct from the canonical PDZ-ligand interactions and located "outside the box" explain PDZ domain specificity. Phosphorylation of NHERF1 by diverse kinases and associated conformational changes in NHERF1 add more complexity to PDZ-binding diversity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
International journal of molecular sciences - 22(2021), 3 vom: 22. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mamonova, Tatyana [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.05.2021 Date Revised 30.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms22031087 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320612279 |
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| 100 | 1 | |a Mamonova, Tatyana |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport |b Binding Outside the Box |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Na+/H+ exchange factor-1 (NHERF1), a multidomain PDZ scaffolding phosphoprotein, is required for the type II sodium-dependent phosphate cotransporter (NPT2A)-mediated renal phosphate absorption. Both PDZ1 and PDZ2 domains are involved in NPT2A-dependent phosphate uptake. Though harboring identical core-binding motifs, PDZ1 and PDZ2 play entirely different roles in hormone-regulated phosphate transport. PDZ1 is required for the interaction with the C-terminal PDZ-binding sequence of NPT2A (-TRL). Remarkably, phosphocycling at Ser290 distant from PDZ1, the penultimate step for both parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) regulation, controls the association between NHERF1 and NPT2A. PDZ2 interacts with the C-terminal PDZ-recognition motif (-TRL) of G Protein-coupled Receptor Kinase 6A (GRK6A), and that promotes phosphorylation of Ser290. The compelling biological puzzle is how PDZ1 and PDZ2 with identical GYGF core-binding motifs specifically recognize distinct binding partners. Binding determinants distinct from the canonical PDZ-ligand interactions and located "outside the box" explain PDZ domain specificity. Phosphorylation of NHERF1 by diverse kinases and associated conformational changes in NHERF1 add more complexity to PDZ-binding diversity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a PDZ domain | |
| 650 | 4 | |a PDZ-ligand interaction | |
| 650 | 4 | |a binding affinity | |
| 650 | 4 | |a parathyroid hormone (PTH) | |
| 650 | 4 | |a phosphate transport | |
| 650 | 4 | |a phosphorylation | |
| 650 | 4 | |a type II sodium-dependent phosphate cotransporter (NPT2A) | |
| 650 | 7 | |a FGF23 protein, human |2 NLM | |
| 650 | 7 | |a Hormones |2 NLM | |
| 650 | 7 | |a Ligands |2 NLM | |
| 650 | 7 | |a Parathyroid Hormone |2 NLM | |
| 650 | 7 | |a Phosphates |2 NLM | |
| 650 | 7 | |a Phosphoproteins |2 NLM | |
| 650 | 7 | |a SLC34A1 protein, human |2 NLM | |
| 650 | 7 | |a Sodium-Hydrogen Exchangers |2 NLM | |
| 650 | 7 | |a Sodium-Phosphate Cotransporter Proteins, Type IIa |2 NLM | |
| 650 | 7 | |a sodium-hydrogen exchanger regulatory factor |2 NLM | |
| 650 | 7 | |a Serine |2 NLM | |
| 650 | 7 | |a 452VLY9402 |2 NLM | |
| 650 | 7 | |a Fibroblast Growth Factor-23 |2 NLM | |
| 650 | 7 | |a 7Q7P4S7RRE |2 NLM | |
| 650 | 7 | |a G-Protein-Coupled Receptor Kinases |2 NLM | |
| 650 | 7 | |a EC 2.7.11.16 |2 NLM | |
| 650 | 7 | |a G-protein-coupled receptor kinase 6 |2 NLM | |
| 650 | 7 | |a EC 2.7.11.16 |2 NLM | |
| 700 | 1 | |a Friedman, Peter A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d 2008 |g 22(2021), 3 vom: 22. Jan. |w (DE-627)NLM185552161 |x 1422-0067 |7 nnns |
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| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijms22031087 |3 Volltext |
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