The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia

© 2021. The Author(s)..

PURPOSE: Impaired angiogenesis is one of the most common findings in preeclamptic placentas. A new angiogenetic role of fractalkine (CX3CL1) is recently recognized apart from inflammatory activity. In this study, a link between CX3CL1 and the development of placental vasculature in preeclampsia was examined.

METHODS: The study comprised 52 women allocated to Group 1 (normotensive, n = 23) and Group 2 (preeclampsia, n = 29). In each group Doppler parameters, serum levels of CX3CL1, soluble fms-like tyrosine kinase-1 (sFlt-1), and placental growth factor (PlGF) were assessed between 30 and 32 week of pregnancy. After the delivery, placental samples were taken and the vascularization and expression of CX3CR1 receptor were assessed after immunostaining.

RESULTS: CX3CL1 and sFlt-1 serum levels were significantly higher levels in Group 2 vs Group 1, while PlGF serum levels was significantly lower in Group 2. Lower cerebroplacental ratio (CPR) was observed in Group 2. The vascular/extravascular tissue index (V/EVTI) was significantly lower in Group 2, while compared to Group 1, with the lowest value in the fetus growth restriction (FGR) subgroup (0.18 ± 0.02; 0.24 ± 0.03; 0.16 ± 0.02, respectively). The expression of examined CX3CR1 was higher in Group 2, while compared to Group 1, reaching the highest values in FGR subgroup. There was a moderate negative correlation between birth weight, V/EVTI and CX3CL1 serum level and CX3CR1 placental expression in the group of pregnancies complicated with preeclampsia.

CONCLUSION: The significant underdevelopment of placental vascular network in preeclampsia is associated with the change in the CX3CL1/CX3CR1 system, especially in FGR complicated pregnancies.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:304

Enthalten in:

Archives of gynecology and obstetrics - 304(2021), 2 vom: 26. Aug., Seite 365-376

Sprache:

Englisch

Beteiligte Personen:

Szewczyk, Grzegorz [VerfasserIn]
Pyzlak, Michał [VerfasserIn]
Pankiewicz, Katarzyna [VerfasserIn]
Szczerba, Ewa [VerfasserIn]
Stangret, Aleksandra [VerfasserIn]
Szukiewicz, Dariusz [VerfasserIn]
Skoda, Marta [VerfasserIn]
Bierła, Joanna [VerfasserIn]
Cukrowska, Bożena [VerfasserIn]
Fijałkowska, Anna [VerfasserIn]

Links:

Volltext

Themen:

144589-93-5
Angiogenesis
Biomarkers
CX3C Chemokine Receptor 1
CX3CR1 protein, human
Chemokine CX3CL1
EC 2.7.10.1
FLT1 protein, human
Fractalkine
Journal Article
Observational Study
Placenta
Placenta Growth Factor
Preeclampsia
Research Support, Non-U.S. Gov't
Vascular Endothelial Growth Factor Receptor-1

Anmerkungen:

Date Completed 28.10.2021

Date Revised 28.10.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00404-021-05966-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM320587983